Revealing False Positive Features in Epileptic EEG Identification.

Feature selection plays a vital role in the detection and discrimination of epileptic seizures in electroencephalogram (EEG) signals. The state-of-the-art EEG classification techniques commonly entail the extraction of the multiple features that would be fed into classifiers. For some techniques, the feature selection strategies have been used to reduce the dimensionality of the entire feature space. However, most of these approaches focus on the performance of classifiers while neglecting the association between the feature and the EEG activity itself. To enhance the inner relationship between the feature subset and the epileptic EEG task with a promising classification accuracy, we propose a machine learning-based pipeline using a novel feature selection algorithm built upon a knockoff filter. First, a number of temporal, spectral, and spatial features are extracted from the raw EEG signals. Second, the proposed feature selection algorithm is exploited to obtain the optimal subgroup of features. Afterwards, three classifiers including [Formula: see text]-nearest neighbor (KNN), random forest (RF) and support vector machine (SVM) are used. The experimental results on the Bonn dataset demonstrate that the proposed approach outperforms the state-of-the-art techniques, with accuracy as high as for normal and interictal EEG discrimination and for interictal and ictal EEG classification. Meanwhile, it has achieved satisfactory sensitivity (95.67% in average), specificity (98.83% in average), and accuracy (98.89% in average) over the Freiburg dataset.