J Pediatr Ophthalmol Strabismus. 2020 May 1;57(3):154-158. doi: 10.3928/01913913-20200219-01.
To examine the clinical profile of sympathetic ophthalmia among the pediatric age group.
Retrospective review of patients 18 years and younger with sympathetic ophthalmia seen in a tertiary eye care center between 1997 and 2017.
Of 20 patients included in the study, 70% were male. The most common inciting event for sympathetic ophthalmia was trauma (85%), followed by vitreoretinal surgery (15%). All patients were treated with systemic steroids. Seventeen patients received additional corticosteroid-sparing immunosuppressive agents, and 4 patients (20%) required more than one immunosuppressive agent. Azathioprine was the most commonly used corticosteroid-sparing immunosuppressive agent. The most common complications were cataract (50%) and ocular hypertension (30%). The mean presenting best corrected visual acuity in the sympathizing eye was 1.15 ± 0.99 logarithm of the minimum angle of resolution (logMAR), which improved to 0.54 ± 1.00 logMAR following treatment. Visual outcome was good (6/12 or better) in 70% of the sympathizing eyes, and 3 of the exciting eyes in the current study had good visual outcomes after the treatment.
Prompt and effective management with corticosteroid-sparing immunosuppressive therapy in children with sympathetic ophthalmia allows favorable control of the disease and retention of good visual acuity. [J Pediatr Ophthalmol Strabismus. 2020;57(3):154-158.].
研究儿童交感眼炎的临床特征。
对 1997 年至 2017 年期间在一家三级眼科中心就诊的 18 岁以下交感眼炎患儿进行回顾性研究。
在纳入研究的 20 名患者中，70%为男性。交感眼炎最常见的激发事件是创伤（85%），其次是眼玻璃体视网膜手术（15%）。所有患者均接受全身皮质类固醇治疗。17 例患者接受了额外的皮质类固醇保留免疫抑制剂治疗，4 例（20%）需要使用一种以上的免疫抑制剂。硫唑嘌呤是最常用的皮质类固醇保留免疫抑制剂。最常见的并发症是白内障（50%）和眼压升高（30%）。患眼的最佳矫正视力平均为 1.15±0.99 最小角分辨率对数（logMAR），治疗后改善至 0.54±1.00 logMAR。70%的患眼视力良好（6/12 或更好），在本研究中，3 只激发眼在治疗后视力良好。
对儿童交感眼炎进行及时有效的皮质类固醇保留免疫抑制治疗，可以很好地控制疾病并保持良好的视力。
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