白细胞介素-6 和褪黑素作为老年人认知、情绪和功能老化的预测指标。
Interleukin-6 and Melatonin as Predictors of Cognitive, Emotional and Functional Ageing of Older People.
机构信息
Laboratory of Theory and Fundamentals of Nursing, Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, ul. Michałowskiego 12, 31-126 Krakow, Poland.
Department of Clinical Nursing, Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, ul. Kopernika 25, 31-501 Krakow, Poland.
出版信息
Int J Environ Res Public Health. 2020 May 21;17(10):3623. doi: 10.3390/ijerph17103623.
BACKGROUND
The ageing process causes a number of changes in the human immune and endocrine systems. The aim of this study was to assess the relationship between cognitive, emotional and functional skills as well lifestyle, versus selected biochemical indicators of the ageing process.
METHODS
The cross-sectional study was conducted in a group of 121 people aged 60-90 residing in the Lesser Poland voivodship. The study used standardized research tools including the Barthel scale, Instrumental Activities of Daily Living (IADL) scale, Mini-Mental State Examination (MMSE), Life Orientation Test (LOT-R) and inventory of health behaviors (IHB). In addition, the concentration of IL-6 and melatonin in the blood plasma was determined.
RESULTS
We determined the correlation between the level of IL-6 in a group of people over 75 years of age (requiring medical care), and results of the IADL scale. There was also a correlation between melatonin levels and the MMSE results in a group of people aged 60-75 who did not require constant medical care.
CONCLUSIONS
IL-6 can be treated as a predictor of functional skills of people over 75 years of age, and melatonin can be perceived as a factor for recognizing cognitive impairment in elderly people who do not require constant medical assistance.
背景
衰老过程会导致人体免疫和内分泌系统发生多种变化。本研究旨在评估认知、情绪和功能技能与生活方式，与衰老过程中选定的生化指标之间的关系。
方法
该横断面研究在居住于小波兰省的 121 名年龄在 60-90 岁的人群中进行。该研究使用了标准化的研究工具，包括巴氏量表、日常生活活动能力量表（IADL）、简易精神状态检查（MMSE）、生活取向测验（LOT-R）和健康行为量表（IHB）。此外，还测定了血浆中白细胞介素 6（IL-6）和褪黑素的浓度。
结果
我们确定了年龄在 75 岁以上（需要医疗护理）人群中白细胞介素 6 水平与 IADL 量表结果之间的相关性。在不需要持续医疗护理的 60-75 岁人群中，褪黑素水平与 MMSE 结果之间也存在相关性。
结论
白细胞介素 6 可以作为 75 岁以上人群功能技能的预测因子，而褪黑素可以作为不需要持续医疗帮助的老年人群认知障碍的识别因素。
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