芳基醇的芳基碳-碳键的脱羟基烷基化卤化反应。
Dehydroxyalkylative halogenation of C(aryl)-C bonds of aryl alcohols.
作者信息
Liu Mingyang, Zhang Zhanrong, Liu Huizhen, Wu Tianbin, Han Buxing
机构信息
Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Chem Commun (Camb). 2020 Jul 4;56(52):7120-7123. doi: 10.1039/d0cc02306j. Epub 2020 May 27.
We herein report Cu mediated side-directed dehydroxyalkylative halogenation of aryl alcohols. C(aryl)-C bonds of aryl alcohols were effectively cleaved, affording the corresponding aryl chlorides, bromides and iodides in excellent yields. Aryl alcohols could serve as both aromatic electrophilic and radical synthetic equivalents during the reaction.
我们在此报告铜介导的芳基醇的侧链导向脱羟基烷基卤化反应。芳基醇的C(芳基)-C键被有效裂解，以优异的产率得到相应的芳基氯化物、溴化物和碘化物。在反应过程中，芳基醇既可以作为芳香亲电试剂，也可以作为自由基合成等效物。
Zotero 插件