尼日利亚男性前列腺癌组织形态学模式的最新情况——以伊巴丹大学学院医院为例

An Update on the Histomorphological Pattern of Carcinoma of the Prostate Gland in Nigerian Men as seen in the University College Hospital, Ibadan.

作者信息

Omenai S A, Mashor M, Adebiyi A, Ogunbiyi J O

机构信息

Department of Pathology, University College Hospital, Ibadan, Nigeria.

Departments of Community Medicine, University College Hospital, Ibadan, Nigeria.

出版信息

West Afr J Med. 2020 Jul-Aug;37(3):248-252.

PMID:32476118

Abstract

OBJECTIVE

Within a multicentre prospective study of prostate cancer genetics, we analysed some parameters of cases seen in our centre over a 2-year period to see if there are any changes in histological grades and age compared to previous studies in this environment.

METHODS

Histological grading and scoring had been done using the revised International Society of urologic pathology (ISUP) system and cases were classified into Grade groups. Gleason grades less than 3 were not assigned and Scores less than 6 not assigned. The Prostatic Specific Antigen (PSA) levels as well as the average tumour percentage in the biopsy specimens were determined.

RESULTS

A hundred and forty-five (145) patients were seen. The majority of patients seen were in Grade group 5 (30.3%), followed by grade group 4 (26.2%) and then groups 1, 3 and 2 in that order. Patients' ages ranged from 47 years to 86 years, with peak age incidence in the 7th decade. PSA values ranged from 3.6 to 22,130ng/ml and tumour volumes ranged from 5% of biopsy tissue to 95%. The lowest PSA value was seen in a patient in grade group 1 but the highest PSA value was recorded in a patient in Grade group 3. The lowest and highest tumour volumes were seen in patients in grade group 4. The PSA and tumour volumes did not vary in linear fashion with Gleason grade.

CONCLUSION

The results show that the majority of patients in Ibadan present with high grade prostatic carcinoma even using the new ISUP grading system but the proportion of highgrade tumours seems higher than in the previous study, likely because more diagnostic tissue has become available per case. Examining a minimum of 12 cores have definitely created an opportunity for proper grading. Peak incidence is in the 7th decade followed by the 8th decade. Very high PSA values recorded in our patients with prostatic carcinoma do not show linear relationship with prostatic carcinoma volume or grade.

摘要

目的

在一项前列腺癌遗传学多中心前瞻性研究中，我们分析了本中心在两年期间所诊治病例的一些参数，以观察与该环境下以往研究相比，组织学分级和年龄是否有任何变化。

方法

使用修订后的国际泌尿病理学会（ISUP）系统进行组织学分级和评分，并将病例分为不同分级组。 Gleason分级小于3的未进行分级，评分小于6的也未进行分级。测定前列腺特异性抗原（PSA）水平以及活检标本中的平均肿瘤百分比。

结果

共诊治了145例患者。所见患者大多数处于5级组（30.3%），其次是4级组（26.2%），然后依次是1级、3级和2级组。患者年龄范围为47岁至86岁，发病高峰年龄在70多岁。PSA值范围为3.6至22130ng/ml，肿瘤体积范围为活检组织的5%至95%。 PSA值最低的见于1级组的一名患者，而PSA值最高的记录于3级组的一名患者。肿瘤体积最小和最大的见于4级组的患者。 PSA和肿瘤体积与Gleason分级并非呈线性变化。

结论

结果表明，即使采用新的ISUP分级系统，伊巴丹的大多数患者仍表现为高级别前列腺癌，但高级别肿瘤的比例似乎高于以往研究，可能是因为每个病例可获得更多的诊断组织。至少检查12个核心标本无疑为准确分级创造了机会。发病高峰年龄在70多岁，其次是80多岁。我们的前列腺癌患者中记录到的非常高的PSA值与前列腺癌体积或分级无线性关系。