由于人类血小板抗原 3a 抗体导致的乘客淋巴细胞减少性血小板减少症：病例报告及文献复习。

Passenger lymphocyte thrombocytopenia due to human platelet antigen 3a antibodies: Case report and review of literature.

机构信息

King's College Hospital NHS Foundation Trust, London, UK.

National Health Service Blood and Transplant, Filton, Bristol, UK.

出版信息

Transfusion. 2020 Oct;60(10):2185-2188. doi: 10.1111/trf.15905. Epub 2020 Jun 11.

DOI:10.1111/trf.15905

PMID:32529693

Abstract

We report a case of severe acute thrombocytopenia occurring within days after a cadaveric liver transplant, received from a female patient with aplastic anemia who died of intracranial bleeding. The donor, who was homozygous for the ITGA2B002 (HPA-3b) gene, had developed human platelet antigen (HPA)-3a antibodies, whereas the recipient was homozygous for the ITGA2B001 (HPA-3a) gene. Thrombocytopenia responded to an infusion of immunoglobulin G. This is the first report of a passenger lymphocyte syndrome manifesting with thrombocytopenia due to anti-HPA-3a. We review the literature on thrombocytopenia in the setting of PLS and discuss the differential diagnosis.

摘要

我们报告了一例在尸体肝移植后数天发生的严重急性血小板减少症，患者为一名因颅内出血而死亡的再生障碍性贫血女性。供体为 ITGA2B002（HPA-3b）基因纯合子，已产生人类血小板抗原（HPA）-3a 抗体，而受者为 ITGA2B001（HPA-3a）基因纯合子。血小板减少症对免疫球蛋白 G 输注有反应。这是首例由于抗 HPA-3a 而表现为血小板减少的过客淋巴细胞综合征的报告。我们复习了 PLS 背景下血小板减少症的文献，并讨论了鉴别诊断。