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一例抗 N-甲基-D-天冬氨酸受体脑炎

A case of anti--methyl-d-aspartate receptor encephalitis.

作者信息

Abdul Rashid Anna Misyail, Mohamad Mokhtar Elmina, Md Noh Mohamad Syafeeq Faeez

机构信息

Department of Medicine, Level 3, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Department of Pathology, Hospital Serdang, Kajang, Malaysia.

出版信息

SAGE Open Med Case Rep. 2020 Jun 3;8:2050313X20926431. doi: 10.1177/2050313X20926431. eCollection 2020.

Abstract

Anti--methyl-d-aspartate receptor encephalitis is characterized by the clinical manifestation of neuropsychiatric symptoms, predominantly affecting young adults, and frequently associated with neoplasms. It is the second most common cause of autoimmune and paraneoplastic encephalitis. Early diagnosis is often missed, as patients are commonly diagnosed with psychiatric illnesses and are treated with antipsychotics - which rarely gives complete resolution of symptoms. Herein, we discuss a patient with mixed clinical, imaging, electroencephalogram, and laboratory findings, with an eventual diagnosis of anti--methyl-d-aspartate receptor encephalitis requiring immunotherapy and operative intervention.

摘要

抗N-甲基-D-天冬氨酸受体脑炎的特征是出现神经精神症状的临床表现,主要影响年轻人,且常与肿瘤相关。它是自身免疫性和副肿瘤性脑炎的第二大常见病因。早期诊断常常被漏诊,因为患者通常被诊断为精神疾病并接受抗精神病药物治疗,而这很少能使症状完全缓解。在此,我们讨论一名具有混合临床、影像学、脑电图和实验室检查结果的患者,最终诊断为抗N-甲基-D-天冬氨酸受体脑炎,需要免疫治疗和手术干预。

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