Chen Xing, Zou Xiao-Jie, Xu Zhen
Department of Pediatrics, Huzhou Central Hospital, Affiliated Cent Hospital HuZhou University, Huzhou 313000, Zhejiang Province, China.
World J Clin Cases. 2020 Jun 6;8(11):2345-2349. doi: 10.12998/wjcc.v8.i11.2345.
A series of recent cases of pneumonia in Wuhan, Hubei Province, China, was caused by the 2019 novel coronavirus [2019-nCoV, also called severe acute respiratory syndrome (SARS)-CoV-2]. The World Health Organization officially named the disease as coronavirus disease 2019 (COVID-19). With the global spread of COVID-19, similar cases have appeared in other areas of China, and there are a few reports of pediatric patients with COVID-19 pneumonia.
A 7-year-old girl was diagnosed with COVID-19 and presented with irregular fever, sore throat and diarrhea. Chest computed tomography revealed patchy consolidation and ground-glass opacities in multiple areas. The lesions were mainly distributed in the bronchial bundles or subpleural areas of both lungs, particularly in the right lower lobe. The patient also presented with diarrhea, mild kidney injury, and live coronavirus was found in her feces. She was given antiviral agents (lopinavir and ritonavir), and follow-up detection showed that these abnormalities were markedly decreased within 3 d.
The clinical symptoms and prognosis of COVID-19 in pediatric patients may be different from those in adult patients, and the fecal-oral transmission of SARS-CoV-2 should be considered.
中国湖北省武汉市近期出现的一系列肺炎病例由2019新型冠状病毒(2019-nCoV,也称为严重急性呼吸综合征冠状病毒2,即SARS-CoV-2)引起。世界卫生组织将该疾病正式命名为2019冠状病毒病(COVID-19)。随着COVID-19在全球范围内传播,中国其他地区也出现了类似病例,并且有一些关于COVID-19肺炎儿科患者的报道。
一名7岁女孩被诊断为COVID-19,表现为不规则发热、咽痛和腹泻。胸部计算机断层扫描显示多个区域有斑片状实变和磨玻璃样混浊。病变主要分布在双肺的支气管束或胸膜下区域,尤其是右下叶。该患者还出现腹泻、轻度肾损伤,并且在其粪便中发现了活冠状病毒。给予其抗病毒药物(洛匹那韦和利托那韦),随访检测显示这些异常在3天内明显减轻。
儿科患者COVID-19的临床症状和预后可能与成人患者不同,应考虑SARS-CoV-2的粪-口传播。