Human Population Biology Research Unit, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Tel Aviv, Israel.
Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.
Osteoporos Int. 2020 Nov;31(11):2197-2208. doi: 10.1007/s00198-020-05504-y. Epub 2020 Jun 16.
The relationship between OA and osteoporosis characteristics remains controversial. This study revealed that age-adjusted hand OA is associated with lower hand/arm BMD levels. Wrist fracture occurrence is associated with increased OA hand scores and low arm BMD. Conversely, age-adjusted knee and spine OA is associated with high spine, hip, and total BMDs.
Osteoarthritis (OA) and osteoporosis are two common musculoskeletal diseases which contribute a high burden of disability, yet assessments of their relationship remains controversial. The aim of this study was to clarify the association between bone mineral densities (BMD) of the hand, arm, spine, hip, and total body, and OA of the hand and knee and lumbar disc degeneration in two different ethnic groups.
Radiographic assessments of the hand, knee, and spine were collected and coded for joint space narrowing, osteophytes, and the Kellgren-Lawrence score from Chuvashian (n = 1504) and British (n = 2280) individuals. BMD measurements of standard skeletal sites were estimated by dual X-ray absorptiometry. Age- and familial-adjusted regression analyses were conducted to determine associations.
Knee OA affection was positively associated with elevated hip, spine, and total body BMD levels (p < 0.001). Additionally, disc degeneration phenotypes showed significant positive associations with the hip, spine, and total BMD (p < 0.001). However, increased hand OA scores was significantly negatively correlated with arm and hand BMD measurements in males and females in both samples (p < 0.001). Additionally, higher hand OA scores were significantly associated with wrist fracture.
We discovered a clear pattern of association between hand OA and low hand and arm BMD, with increased risk of wrist fracture, as well as reproducing previous associations between knee and spine OA and elevated spine, hip, and total body BMD. It appears that hand OA manifests differently in comparison to hip and knee OA.
骨关节炎（OA）和骨质疏松症是两种常见的肌肉骨骼疾病，它们导致了很高的残疾负担，但对它们之间关系的评估仍然存在争议。本研究的目的是阐明手部、手部和膝部 OA 与腰椎间盘退变与手部、臂部、脊柱、髋部和全身骨密度（BMD）之间的关系。
从楚瓦什人（n=1504）和英国人（n=2280）中收集手部、膝关节和脊柱的影像学评估结果，并对关节间隙变窄、骨赘和 Kellgren-Lawrence 评分进行编码。通过双能 X 线吸收法估计标准骨骼部位的 BMD 测量值。采用年龄和家族调整回归分析来确定关联。
膝 OA 与髋部、脊柱和全身 BMD 水平升高呈正相关（p<0.001）。此外，椎间盘退变表型与髋部、脊柱和全身 BMD 呈显著正相关（p<0.001）。然而，在两个样本中，男性和女性的手部 OA 评分增加与手臂和手部 BMD 测量值显著负相关（p<0.001）。此外，手部 OA 评分较高与腕部骨折显著相关。
我们发现手部 OA 与手部和手臂 BMD 降低以及腕部骨折风险增加之间存在明显的关联模式，这与之前报道的髋部和膝部 OA 与脊柱、髋部和全身 BMD 升高之间的关联一致。手部 OA 与髋部和膝部 OA 的表现似乎不同。
