头颈部鳞状癌前病变中PD-L1表达的患病率：一项系统评价和荟萃分析。
Prevalence of PD-L1 expression in head and neck squamous precancerous lesions: a systematic review and meta-analysis.
作者信息
Girolami Ilaria, Pantanowitz Liron, Munari Enrico, Martini Maurizio, Nocini Riccardo, Bisi Nicola, Molteni Gabriele, Marchioni Daniele, Ghimenton Claudio, Brunelli Matteo, Eccher Albino
机构信息
Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
出版信息
Head Neck. 2020 Oct;42(10):3018-3030. doi: 10.1002/hed.26339. Epub 2020 Jun 22.
BACKGROUND
Studies concerning programmed death-ligand 1 (PD-L1) expression in precancerous lesions of head and neck (HN) region have shown variable results.
METHODS
We systematically reviewed the published evidence on PD-L1 expression in HN precancerous lesions.
RESULTS
Of 1058 original articles, 14 were included in systematic review and 9 in meta-analysis. The pooled estimate of PD-L1 expression was 48.25% (confidence interval [CI] 21.07-75.98, I 98%, tau2 0.18). PD-L1 expression appeared to be more frequent in precancerous lesions than in normal mucosa (risk ratio [RR] 1.65, CI 0.65-4.03, I 91%, tau2 0.82) and less frequent than in invasive squamous cell carcinoma (RR 0.68, CI 0.43-1.08, I 91%, tau2 0.22).
CONCLUSIONS
PD-L1 expression could reflect a point of balance between host immune response and cancer escape ability. High heterogeneity and moderate quality suggest that further studies with larger sample size and more rigorous case selection will allow more precise assessment of PD-L1 expression in HN precancerous lesions.
背景
关于头颈部（HN）区域癌前病变中程序性死亡配体1（PD-L1）表达的研究结果不一。
方法
我们系统回顾了已发表的关于HN癌前病变中PD-L1表达的证据。
结果
在1058篇原始文章中，14篇纳入系统评价，9篇纳入荟萃分析。PD-L1表达的合并估计值为48.25%（置信区间[CI]21.07 - 75.98，I² 98%，τ² 0.18）。PD-L1表达在癌前病变中似乎比在正常黏膜中更常见（风险比[RR]1.65，CI 0.65 - 4.03，I² 91%，τ² 0.82），且比浸润性鳞状细胞癌中更少见（RR 0.68，CI 0.43 - 1.08，I² 91%，τ² 0.22）。
结论
PD-L1表达可反映宿主免疫反应与癌症逃逸能力之间的平衡状态。高异质性和中等质量表明，进一步开展更大样本量、更严格病例选择的研究将有助于更精确地评估HN癌前病变中PD-L1的表达情况。
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