ACE2 与肾素-血管紧张素系统其他成分的关系。
Relationship Between ACE2 and Other Components of the Renin-Angiotensin System.
机构信息
Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Curr Hypertens Rep. 2020 Jun 26;22(7):44. doi: 10.1007/s11906-020-01048-y.
PURPOSE OF THE REVIEW
Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection.
RECENT FINDINGS
ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.
本次综述的目的
血管紧张素转换酶 2（ACE2）是肾素-血管紧张素系统（RAS）的关键代偿性组成部分。在这里，我们简要回顾了与 ACE2 活性相关的机制和靶器官效应，以及 ACE2 在 SARS-CoV-2 感染中的重要性。
最近的发现
ACE2 将血管紧张素（Ang）II 转化为 Ang-(1-7)，直接拮抗 Ang II 的血管收缩、促炎和促血栓形成作用。ACE2 还促进 SARS-CoV-2 病毒进入宿主细胞。与肾素-血管紧张素系统相互作用的药物可能会影响 ACE2 的表达和 COVID-19 的发病机制；然而，目前尚不清楚这些影响的程度和方向。需要高质量的研究来提高我们对作用于肾素-血管紧张素系统的药物如何影响 ACE2 和 COVID-19 相关疾病结局的理解。
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