结直肠癌腹膜转移切除的治疗结果。
Treatment Outcome of Resection of Disseminated Peritoneal Metastases from Colorectal Cancer.
机构信息
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
出版信息
In Vivo. 2020 Jul-Aug;34(4):1915-1920. doi: 10.21873/invivo.11988.
AIM
To show the treatment outcomes of disseminated nodule resection for peritoneal metastasis of colorectal cancer and describe the details of cured cases.
PATIENTS AND METHODS
From January 2001 to December 2016, patients who underwent disseminated nodule resection of colorectal adenocarcinoma with no macroscopic residual tumor in our institution were retrospectively analyzed for clinicopathological factors associated with prognosis.
RESULTS
Forty-one cases were included in this study. The 3-year relapse-free survival was 12.5%, and the 5-year overall survival was 38.4%. In a multivariate analysis, lack of post-operative adjuvant chemotherapy and pre-operative carbohydrate antigen 19-9 over 100 IU/l were extracted as independent factors associated with short relapse-free survival, respectively. Among 41 cases, 32 were followed-up 5 years after surgery and five (15.6%) survived without relapse and were regarded as 'cured'.
CONCLUSION
More than a few cases of colorectal peritoneal metastasis, which is thought to be difficult to cure, were cured by resection of disseminated nodules without resorting to highly invasive treatment.
目的
展示结直肠腺癌腹膜转移散在结节切除的治疗效果，并描述治愈病例的详细情况。
患者与方法
本研究回顾性分析了 2001 年 1 月至 2016 年 12 月期间在我院接受结直肠腺癌散在结节切除术且无肉眼残留肿瘤的患者的临床病理因素与预后的关系。
结果
本研究共纳入 41 例患者。3 年无复发生存率为 12.5%，5 年总生存率为 38.4%。多因素分析显示，术后缺乏辅助化疗和术前糖类抗原 19-9 超过 100IU/L 是与无复发生存时间短相关的独立因素。41 例患者中，32 例术后随访 5 年，5 例（15.6%）无复发且存活，被视为“治愈”。
结论
通过不采用高侵袭性治疗的散在结节切除，治愈了几例被认为难以治愈的结直肠腹膜转移病例。
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