睡眠和清醒状态下的结构性突触可塑性
Structural synaptic plasticity across sleep and wake.
作者信息
Bellesi Michele, de Vivo Luisa
机构信息
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, BS8 1TD Bristol, UK.
出版信息
Curr Opin Physiol. 2020 Jun;15:74-81. doi: 10.1016/j.cophys.2019.12.007.
Sleep-dependent synaptic plasticity is crucial for optimal cognition. However, establishing the direction of synaptic plasticity during sleep has been particularly challenging since data in support of both synaptic potentiation and depotentiation have been reported. This review focuses on structural synaptic plasticity across sleep and wake and summarizes recent developments in the use of 3-dimensional electron microscopy as applied to this field.
睡眠依赖的突触可塑性对于最佳认知至关重要。然而，确定睡眠期间突触可塑性的方向一直特别具有挑战性，因为支持突触增强和突触减弱的数据均有报道。本综述聚焦于睡眠和清醒状态下的突触结构可塑性，并总结了应用于该领域的三维电子显微镜技术的最新进展。
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