衰老、炎症与造血干细胞。
Aging, inflammation, and HSC.
机构信息
University of Colorado Anschutz Medical Campus.
出版信息
Blood. 2020 Jul 9;136(2):153-154. doi: 10.1182/blood.2020006070.
Abstract
In this issue of , He et al show that a tumor necrosis factor α (TNFα)-mediated pathway regulating interleukin-27 receptor subunit α (IL-27Ra) expression on hematopoietic stem cells (HSCs) mediates changes in HSCs that occur in old age, including myeloid skewing, reduced reconstitution potential, impaired self-renewal, and a proinflammatory phenotype.
摘要
本期杂志中，何等人研究表明，肿瘤坏死因子α（TNFα）调节造血干细胞（HSCs）白细胞介素-27 受体亚基α（IL-27Ra）表达的途径，介导了衰老过程中 HSCs 发生的变化，包括骨髓偏向、重建能力降低、自我更新受损和促炎表型。
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