Division of Neurocritical Care, Departments of Neurology and Neurosurgery, NYU Langone Medical Center, 530 First Avenue, HCC-5A, New York, NY, 10016, USA.
NYU School of Medicine, 530 First Avenue, New York, NY, USA.
Neurocrit Care. 2021 Apr;34(2):473-484. doi: 10.1007/s12028-020-01039-6.
We sought to identify similarities and differences in the diagnostic requirements for ancillary testing for determination of brain death/death by neurologic criteria (BD/DNC) around the world.
We reviewed diagnostic requirements for ancillary testing for BD/DNC in 78 unique official national BD/DNC protocols obtained from contacts worldwide between January 2018 and April 2019.
Details provided on the performance and interpretation of ancillary tests for determination of BD/DNC were variably provided and inconsistent. Approximately half of all protocols that included each ancillary test provided details about study performance: 63% of protocols that included conventional cerebral angiography, 55% of protocols that included electroencephalography, 50% of protocols that included somatosensory evoked potentials, 48% of protocols that included transcranial Doppler ultrasonography, 43% of protocols that included nuclear medicine flow study and 41% of protocols that included brainstem auditory evoked potentials. Similarly, about half of all protocols that included each ancillary test provided details about study interpretation: 66% of protocols that included electroencephalography, 59% of protocols that included brainstem auditory evoked potentials, 56% of protocols that included somatosensory evoked potentials, 55% of protocols that included transcranial Doppler ultrasonography, 52% of protocols that included conventional cerebral angiography and 49% of protocols that included nuclear medicine flow study.
Diagnostic requirements for ancillary testing in BD/DNC determination vary around the world. We hope that the World Brain Death Project will improve worldwide consensus on the diagnostic requirements for ancillary testing in BD/DNC, both for performance and interpretation.
我们旨在确定全球范围内确定脑死亡/神经标准死亡(BD/DNC)的辅助检查诊断要求的异同。
我们回顾了 2018 年 1 月至 2019 年 4 月期间与全球各地的联系人获得的 78 份独特的官方国家 BD/DNC 方案中,用于确定 BD/DNC 的辅助检查的诊断要求。
BD/DNC 辅助检查的性能和解释提供的细节存在差异且不一致。大约一半的包含每个辅助检查的方案提供了关于研究性能的详细信息:包括常规脑血管造影术的方案占 63%,包括脑电图的方案占 55%,包括体感诱发电位的方案占 50%,包括经颅多普勒超声的方案占 48%,包括核医学流量研究的方案占 43%,包括脑干听觉诱发电位的方案占 41%。同样,大约一半的包含每个辅助检查的方案提供了关于研究解释的详细信息:包括脑电图的方案占 66%,包括脑干听觉诱发电位的方案占 59%,包括体感诱发电位的方案占 56%,包括经颅多普勒超声的方案占 55%,包括常规脑血管造影术的方案占 52%,包括核医学流量研究的方案占 49%。
BD/DNC 确定中辅助检查的诊断要求在全球范围内有所不同。我们希望世界脑死亡项目将提高全球范围内对 BD/DNC 中辅助检查的诊断要求的共识,包括性能和解释。