阿片类药物使用障碍与剖宫产术后产妇结局：2007-2014 年多州分析。
Opioid use disorder and maternal outcomes following cesarean delivery: a multistate analysis, 2007-2014.
机构信息
Weill Cornell Medicine, Center for Perioperative Outcomes, Department of Anesthesiology, 428 East 72nd Street, Suite 800A, New York, NY 10021, USA.
Weill Cornell Medicine, Department of Anesthesiology, 525 East 68th Street, Box 124, New York, NY 10065, USA.
出版信息
J Comp Eff Res. 2020 Jul;9(10):667-677. doi: 10.2217/cer-2020-0050. Epub 2020 Jul 10.
To examine the association between opioid use disorder (OUD) and maternal outcomes following cesarean delivery. Retrospective analysis of over 2.4 million discharge records for in-patient cesarean delivery across five states from 2007 to 2014. Primary outcome was in-hospital mortality. Secondary outcomes included length of stay (LOS) and 30- and 90-day readmission rates. OUD patients were 148% more likely than non-OUD patients to die during hospitalization (adjusted odds ratios [aOR]: 2.48, 95% CI: 1.20, 5.10; p < 0.05). OUD was associated with increased odds of 30-day readmission (aOR: 1.46, 95% CI: 1.30, 1.65; p < 0.001) and 90-day readmission (aOR: 1.70, 95% CI: 1.55, 1.88; p < 0.001); LOS was not significantly different. OUD predicts increased in-patient mortality and odds of 30- and 90-day readmission following cesarean delivery.
目的
探讨剖宫产术后阿片类药物使用障碍（OUD）与产妇结局的关系。 方法：对 2007 年至 2014 年五个州超过 240 万例住院剖宫产分娩记录进行回顾性分析。主要结局为院内死亡率。次要结局包括住院时间（LOS）和 30 天及 90 天再入院率。 结果：OUD 患者住院期间死亡的可能性是非 OUD 患者的 148%（调整优势比 [aOR]：2.48，95%CI：1.20，5.10；p < 0.05）。OUD 与 30 天再入院（aOR：1.46，95%CI：1.30，1.65；p < 0.001）和 90 天再入院（aOR：1.70，95%CI：1.55，1.88；p < 0.001）的可能性增加相关；LOS 无显著差异。 OUD 预测剖宫产术后住院死亡率增加，以及 30 天和 90 天再入院的几率增加。
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