脑内血管紧张素 1 型和 2 型受体在生理和高血压条件下的作用：聚焦神经炎症。
Brain Angiotensin Type-1 and Type-2 Receptors in Physiological and Hypertensive Conditions: Focus on Neuroinflammation.
机构信息
Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL, USA.
Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.
出版信息
Curr Hypertens Rep. 2020 Jul 13;22(7):48. doi: 10.1007/s11906-020-01062-0.
PURPOSE OF REVIEW
To review recent data that suggest opposing effects of brain angiotensin type-1 (ATR) and type-2 (ATR) receptors on blood pressure (BP). Here, we discuss recent studies that suggest pro-hypertensive and pro-inflammatory actions of ATR and anti-hypertensive and anti-inflammatory actions of ATR. Further, we propose mechanisms for the interplay between brain angiotensin receptors and neuroinflammation in hypertension.
RECENT FINDINGS
The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular physiology. This includes brain ATR and ATR, both of which are expressed in or adjacent to brain regions that control BP. Activation of ATR within those brain regions mediate increases in BP and cause neuroinflammation, which augments the BP increase in hypertension. The fact that ATR and ATR have opposing actions on BP suggests that ATR and ATR may have similar opposing actions on neuroinflammation. However, the mechanisms by which brain ATR and ATR mediate neuroinflammatory responses remain unclear. The interplay between brain angiotensin receptor subtypes and neuroinflammation exacerbates or protects against hypertension.
目的综述
综述近期资料提示脑血管紧张素 1 型（ATR）和 2 型（ATR）受体对血压（BP）具有相反的影响。在这里，我们讨论了提示 ATR 具有升压和促炎作用以及 ATR 具有降压和抗炎作用的近期研究。此外，我们提出了脑血管紧张素受体与高血压神经炎症相互作用的机制。
最新发现
肾素-血管紧张素系统（RAS）在调节心血管生理学方面发挥着重要作用。这包括脑 ATR 和 ATR，它们均在控制血压的脑区表达或毗邻表达。这些脑区的 ATR 激活介导 BP 的增加，并导致神经炎症，从而增强高血压中的 BP 增加。ATR 和 ATR 对 BP 具有相反作用的事实表明，ATR 和 ATR 可能对神经炎症具有相似的相反作用。然而，脑 ATR 和 ATR 介导神经炎症反应的机制尚不清楚。脑血管紧张素受体亚型与神经炎症的相互作用加重或保护高血压。
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