与克罗恩病相关的强直性脊柱炎中的人类白细胞抗原（HLA）。HLA表型B27、B44频率增加。
HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44.
作者信息
Purrmann J, Zeidler H, Bertrams J, Juli E, Cleveland S, Berges W, Gemsa R, Specker C, Reis H E
机构信息
Department of Gastroenterology, University of Düsseldorf, FRG.
出版信息
J Rheumatol. 1988 Nov;15(11):1658-61.
In a consecutive case study 231 patients with Crohn's disease were investigated for ankylosing spondylitis (AS) and HLA-A, B, C, DR antigen association. Eighteen patients (7.8%) had definite AS according to the New York criteria; 13 (72%) were HLA-B27 positive. The phenotype B27,B44 was seen in 8 patients (44%) compared to only 3 (1%) of 300 controls (p less than 10(-7), and 1 (0.5%) of 213 patients with Crohn's disease without AS (p less than 10(-7). We conclude that patients with the phenotype B27,B44 are highly at risk (relative risk = 68.8) for the common manifestation of Crohn's disease and AS.
在一项连续病例研究中，对231例克罗恩病患者进行了强直性脊柱炎（AS）以及HLA - A、B、C、DR抗原相关性调查。根据纽约标准，18例患者（7.8%）患有确诊的AS；其中13例（72%）HLA - B27呈阳性。与300名对照者中仅3例（1%）（p<10⁻⁷）以及213例无AS的克罗恩病患者中1例（0.5%）（p<10⁻⁷）相比，8例患者（44%）表现为B27、B44型。我们得出结论，具有B27、B44型的患者发生克罗恩病和AS共同表现的风险极高（相对风险=68.8）。
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