青少年和青年急性淋巴细胞白血病患者的低丙种球蛋白血症。
Hypogammaglobulinemia in Adolescents and Young Adults with Acute Lymphoblastic Leukemia.
机构信息
Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Pediatric Hematology and Oncology, Riley Hospital for Children, Indianapolis, Indiana, USA.
出版信息
J Adolesc Young Adult Oncol. 2020 Dec;9(6):687-692. doi: 10.1089/jayao.2020.0060. Epub 2020 Jul 13.
Hypogammaglobulinemia is a poorly described complication of chemotherapy in adolescents and young adults (AYAs, 15-39 years) with acute lymphoblastic leukemia (ALL). The majority of AYAs treated on a Berlin-Frankfurt-Munster-based ALL regimen experienced hypogammaglobulinemia (65.0% [13/20]). Febrile neutropenia episodes (throughout the treatment course) and infectious events during maintenance occurred more frequently in hypogammaglobulinemic patients compared with patients with normal immunoglobulin G levels ( = 7) (median 1.0 vs. 0.0, = 0.02; 7.0 vs. 3.0, = 0.02, respectively). Hypogammaglobulinemia did not impact overall or event-free survival. Further studies are needed to elucidate the etiology of hypogammaglobulinemia and to establish criteria for immunoglobulin replacement in these patients.
低丙种球蛋白血症是青少年和年轻成人（15-39 岁）急性淋巴细胞白血病（ALL）化疗中描述不佳的并发症。在基于柏林-法兰克福-慕尼黑 ALL 方案治疗的大多数 AYA 中，出现低丙种球蛋白血症（65.0% [13/20]）。与免疫球蛋白 G 水平正常的患者相比，低丙种球蛋白血症患者更常发生发热性中性粒细胞减少症发作（整个治疗过程中）和维持期感染事件（= 7）（中位数 1.0 与 0.0，= 0.02；7.0 与 3.0，= 0.02）。低丙种球蛋白血症并不影响总生存或无事件生存。需要进一步研究阐明低丙种球蛋白血症的病因，并为这些患者建立免疫球蛋白替代的标准。
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