成年生长激素缺乏症男性和女性患者内脏脂肪与骨密度之间的关联。
Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency.
作者信息
Li Linman, Zhong Li, Zheng Xiaoya, You Wenyi, Wang Yunting, Yu Jihui, Wu Xun, Ren Wei, Yang Gangyi
机构信息
Department of Health Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
出版信息
Biochem Res Int. 2020 Jul 5;2020:5079625. doi: 10.1155/2020/5079625. eCollection 2020.
AIM
Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD.
METHODS
We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients.
RESULTS
Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, < 0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all < 0.05); however, this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD.
CONCLUSIONS
A close correlation was noted between VATM and BMD in female patients with AGHD.
目的
成人生长激素缺乏症（AGHD）与骨折风险增加相关。已知身体各组成部分与骨骼之间的相互作用本质上很复杂。然而，很少有研究探讨AGHD中的这种相互关系。在本研究中，我们试图调查身体组成的各种参数与骨密度（BMD）之间的关系，并确定内脏脂肪在AGHD患者骨量决定中的作用。
方法
我们对57例AGHD患者进行了横断面研究。根据标准方案进行人体测量、生化分析以及身体组成和BMD分析。将男性和女性患者分为骨质疏松患者和非骨质疏松患者（正常受试者和骨量减少患者）。此外，我们分析了男性和女性AGHD患者BMD与各种身体组成参数测量值之间的相关性。
结果
我们的研究结果表明，在女性AGHD患者中，骨质疏松患者的脂肪量（FM）和内脏脂肪组织量（VATM）水平均显著高于非骨质疏松患者（均P<0.05）。此外，Pearson相关性分析显示，AGHD女性患者的年龄、体重指数（BMI）、FM和VATM值与BMD呈负相关（均P<0.05）；然而，在男性中未发现这种关联。在对其他协变量进行调整后，发现VATM与女性AGHD患者的BMD独立相关。
结论
在女性AGHD患者中，VATM与BMD之间存在密切相关性。
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