Detsi Anastasia, Kavetsou Eleni, Kostopoulou Ioanna, Pitterou Ioanna, Pontillo Antonella Rozaria Nefeli, Tzani Andromachi, Christodoulou Paris, Siliachli Aristeia, Zoumpoulakis Panagiotis
Department of Chemical Sciences, Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, 15780 Athens, Greece.
Institute of Chemical Biology, National Hellenic Research Foundation, Vassileos Constantinou Ave. 48, 116 35 Athens, Greece.
Pharmaceutics. 2020 Jul 16;12(7):669. doi: 10.3390/pharmaceutics12070669.
Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly interesting biomaterialover the past few years. It constitutes a novel perspective in drug delivery systems and nanocarriers' formulations due to its beneficial properties, including biocompatibility, biodegradability and low toxicity. The potentiality of chemical or enzymatic modifications of the biopolymer, as well as its complementary use with other polymers, further attract the scientific community, offering improved and combined properties in the final materials. As a result, chitosan has been extensively used as a matrix for the encapsulation of several valuable compounds. In this review article, the advantageous character of chitosan as a matrix for nanosystemsis presented, focusing on the encapsulation of natural products. A five-year literature review is attempted covering the use of chitosan and modified chitosan as matrices and coatings for the encapsulation of natural extracts, essential oils or pure naturally occurring bioactive compounds are discussed.
壳聚糖是一种阳离子天然多糖，在过去几年中已成为一种越来越受关注的生物材料。由于其具有生物相容性、可生物降解性和低毒性等有益特性，它在药物递送系统和纳米载体配方中构成了一种新的视角。生物聚合物的化学或酶促修饰潜力，以及它与其他聚合物的互补使用，进一步吸引了科学界，为最终材料提供了改进的综合性能。因此，壳聚糖已被广泛用作封装几种有价值化合物的基质。在这篇综述文章中，介绍了壳聚糖作为纳米系统基质的优势特性，重点是天然产物的封装。本文尝试进行了为期五年的文献综述，讨论了壳聚糖和改性壳聚糖作为基质和涂层用于封装天然提取物、精油或纯天然存在的生物活性化合物的情况。
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