血清三叶因子 3 与内镜诊断幽门螺杆菌相关性胃溃疡的比较。
Comparison of Serum Trefoil Factor-3 to Endoscopy in Diagnosing Helicobacter Pylori Associated Gastric Ulcer.
机构信息
Chemical Pathology, Medical Research Institute, Alexandria University, Egypt.
Departments of Internal Medicine, Medical Research Institute, Alexandria University, Egypt.
出版信息
Asian Pac J Cancer Prev. 2020 Jul 1;21(7):2149-2153. doi: 10.31557/APJCP.2020.21.7.2149.
BACKGROUND AND AIM OF THE WORK
Helicobacter pylori-associated gastric ulcer (H.pylori-GU) is a serious condition, not only because H.pylori is identified as a grade 1 carcinogen but also because GU is a precancerous condition. Identification and treatment of H.pylori-GU may prevent the sequential progression of dysplasia to carcinoma. Trefoil factor 3 (Tf3) has been implicated in gastric mucosal repair. We compared serum Tf3 to gastric endoscopy in diagnosing H.pylori-GU.
SUBJECTS AND METHODS
The study included eighty patients suffering from H.pylori induced gastritis, forty of which presented with GU. Gastric endoscopy with slide urease test was used to diagnose H.pylori-GU. Serum Tf3 level was determined using an enzyme immunoassay in all patients as well as thirty healthy volunteers.
RESULTS
Serum Tf3 showed a significant stepwise decrease among the studied groups. It was significantly lower in patients compared to the control group (p<0.001). Furthermore, it was lower in those with GU compared to those without GU (p=0.023). Based on a receiver operating characteristic curve generated cut off value of 2.4 ng/mL, the diagnostic performance of serum Tf3 as a biomarker of H.pylori-GU revealed a diagnostic specificity of 42.5%, sensitivity of 67.5%, positive and negative predictive values of 54% and 56.67% respectively.
CONCLUSION
Although serum Tf3 showed significant variation in H.pylori-GU, further studies are warranted to confirm its role in the pathogenesis of gastric ulcers.
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背景与目的
幽门螺杆菌相关性胃溃疡（H.pylori-GU）是一种严重的疾病，不仅因为幽门螺杆菌被确定为一级致癌物质，还因为 GU 是一种癌前病变。识别和治疗 H.pylori-GU 可能会阻止异型增生发展为癌。三叶因子 3（Tf3）已被认为与胃黏膜修复有关。我们比较了血清 Tf3 与胃内窥镜检查在诊断 H.pylori-GU 中的作用。
对象和方法
该研究纳入了 80 名患有幽门螺杆菌引起的胃炎的患者，其中 40 名患有 GU。胃内窥镜检查结合滑动尿酶试验用于诊断 H.pylori-GU。所有患者及 30 名健康志愿者均采用酶联免疫吸附试验测定血清 Tf3 水平。
结果
在研究组中，血清 Tf3 呈明显的逐步下降。与对照组相比，患者的血清 Tf3 水平显著降低（p<0.001）。此外，GU 患者的血清 Tf3 水平明显低于无 GU 患者（p=0.023）。根据生成的受试者工作特征曲线，血清 Tf3 作为 H.pylori-GU 生物标志物的诊断性能显示出 42.5%的特异性、67.5%的敏感性、54%的阳性预测值和 56.67%的阴性预测值。
结论
虽然血清 Tf3 在 H.pylori-GU 中显示出显著变化，但仍需要进一步研究来证实其在胃溃疡发病机制中的作用。
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