Department of Orthopaedics, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Bone Joint J. 2020 Aug;102-B(8):967-980. doi: 10.1302/0301-620X.102B8.BJJ-2019-1465.R1.
The aims of this study were to validate the outcome of total elbow arthroplasty (TEA) in patients with rheumatoid arthritis (RA), and to identify factors that affect the outcome.
We searched PubMed, MEDLINE, Cochrane Reviews, and Embase from between January 2003 and March 2019. The primary aim was to determine the implant failure rate, the mode of failure, and risk factors predisposing to failure. A secondary aim was to identify the overall complication rate, associated risk factors, and clinical performance. A meta-regression analysis was completed to identify the association between each parameter with the outcome.
A total of 38 studies including 2,118 TEAs were included in the study. The mean follow-up was 80.9 months (8.2 to 156). The implant failure and complication rates were 16.1% (95% confidence interval (CI) 0.128 to 0.200) and 24.5% (95% CI 0.203 to 0.293), respectively. Aseptic loosening was the most common mode of failure (9.5%; 95% CI 0.071 to 0.124). The mean postoperative ranges of motion (ROMs) were: flexion 131.5° (124.2° to 138.8°), extension 29.3° (26.8° to 31.9°), pronation 74.0° (67.8° to 80.2°), and supination 72.5° (69.5° to 75.5°), and the mean postoperative Mayo Elbow Performance Score (MEPS) was 89.3 (95% CI 86.9 to 91.6). The meta-regression analysis identified that younger patients and implants with an unlinked design correlated with higher failure rates. Younger patients were associated with increased complications, while female patients and an unlinked prosthesis were associated with aseptic loosening.
TEA continues to provide satisfactory results for patients with RA. However, it is associated with a substantially higher implant failure and complication rates compared with hip and knee arthroplasties. The patient's age, sex, and whether cemented fixation and unlinked prosthesis were used can influence the outcome. Level of Evidence: Therapeutic Level IV. Cite this article: 2020;102-B(8):967-980.
本研究旨在验证全肘关节置换术(TEA)治疗类风湿关节炎(RA)患者的疗效,并确定影响疗效的因素。
我们检索了 2003 年 1 月至 2019 年 3 月期间的 PubMed、MEDLINE、Cochrane 评价和 Embase 数据库。主要目的是确定假体失败率、失败模式和导致失败的易患因素。次要目的是确定总体并发症发生率、相关危险因素和临床疗效。采用荟萃回归分析确定每个参数与结果之间的关联。
共纳入 38 项研究,包括 2118 例 TEA。平均随访时间为 80.9 个月(8.2-156)。假体失败率和并发症发生率分别为 16.1%(95%可信区间:0.128-0.200)和 24.5%(95%可信区间:0.203-0.293)。无菌性松动是最常见的失败模式(9.5%;95%可信区间:0.071-0.124)。术后平均关节活动度(ROM)为:屈曲 131.5°(124.2°-138.8°),伸展 29.3°(26.8°-31.9°),旋前 74.0°(67.8°-80.2°),旋后 72.5°(69.5°-75.5°),术后平均 Mayo 肘关节功能评分(MEPS)为 89.3(95%可信区间:86.9-91.6)。荟萃回归分析发现,年轻患者和非连接设计的假体与更高的失败率相关。年轻患者与并发症增加相关,而女性患者和非连接假体与无菌性松动相关。
TEA 为 RA 患者提供了满意的疗效。但与髋关节和膝关节置换术相比,TEA 的假体失败和并发症发生率显著更高。患者年龄、性别以及是否采用骨水泥固定和非连接假体等因素会影响疗效。
治疗性研究 IV 级。