儿童维生素A水平与难治性支原体肺炎（RMPP）发病率之间的相关性。
The correlation between vitamin a status and refractory Mycoplasma Pneumoniae pneumonia (RMPP) incidence in children.
作者信息
Li Yuanyuan, Guo Ziyao, Zhang Guangli, Tian Xiaoyin, Li Qinyuan, Chen Dapeng, Luo Zhengxiu
机构信息
Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing, 400014, China.
Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders, Department of Children's Hospital of Chongqing Medical University of Education, Chongqing, 400014, China.
出版信息
BMC Pediatr. 2020 Jul 30;20(1):359. doi: 10.1186/s12887-020-02254-y.
BACKGROUND
Vitamin A plays a pivotal role in respiratory infection, accurate estimation of vitamin A status was recommended in planning and implementing interventions. As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP). Mycoplasma pneumoniae is an important cause of respiratory infection in children, the association between vitamin A concentrations and refractory Mycoplasma pneumoniae pneumonia (RMPP) remains unclear.
METHODS
181 MPP patients were enrolled in this retrospective study, adjusted vitamin A concentrations and other parameters were compared between RMPP and general-MPP (GMPP) patients. Multivariate logistic regression test was performed to evaluate the association between vitamin A levels and RMPP incidence, linear correlation tests were applied to evaluate correlation between vitamin A concentrations and fever duration, length of stay (LOS).
RESULTS
Vitamin A concentrations in RMPP group were significantly lower than those in GMPP patients (P < 0.05), vitamin A (OR = 0.795, 95% C. I 0.669-0.946) and CRP (OR = 1.050, 95% C. I 1.014-1.087) were independently associated with RMPP incidence. Linear correlation tests found vitamin A concentrations were negatively correlated with fever duration and LOS (P < 0.001).
CONCLUSIONS
Serum vitamin A concentrations were independently associated with RMPP incidence, which may correlate with reduced incidence of RMPP.
背景
维生素A在呼吸道感染中起关键作用，在规划和实施干预措施时建议准确评估维生素A状态。由于感染会影响血清维生素A的产生，实际状态需要通过急性期蛋白（APP）进行调整。肺炎支原体是儿童呼吸道感染的重要原因，维生素A浓度与难治性肺炎支原体肺炎（RMPP）之间的关联仍不清楚。
方法
本回顾性研究纳入了181例MPP患者，比较了RMPP患者和普通MPP（GMPP）患者的校正维生素A浓度及其他参数。进行多因素逻辑回归检验以评估维生素A水平与RMPP发病率之间的关联，应用线性相关检验评估维生素A浓度与发热持续时间、住院时间（LOS）之间的相关性。
结果
RMPP组的维生素A浓度显著低于GMPP患者（P < 0.05），维生素A（OR = 0.795，95%置信区间0.669 - 0.946）和CRP（OR = 1.050，95%置信区间1.014 - 1.087）与RMPP发病率独立相关。线性相关检验发现维生素A浓度与发热持续时间和LOS呈负相关（P < 0.001）。
结论
血清维生素A浓度与RMPP发病率独立相关，这可能与RMPP发病率降低有关。
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