Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641-046; Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641-043, India.
Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641-043, India.
BMB Rep. 2020 Aug;53(8):400-412. doi: 10.5483/BMBRep.2020.53.8.121.
The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Since the immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The use of stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSCExos have immunomodulatory functions; they can be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19. [BMB Reports 2020; 53(8): 400-412].
世界见证了由新型冠状病毒病（COVID-19）大流行造成的难以想象的破坏。由于大流行正在迅速发展，因此必须考虑多种治疗方案，以便在全球范围内有效地治疗人们。由于免疫系统是感染的中心，因此必须调节动态平衡，以防止随后导致多器官损伤的过度夸大的免疫反应。在过去十年中，干细胞作为治疗选择已获得巨大动力。科学上的革命性措施为世界带来了间充质干细胞（MSCs）和 MSC 衍生的外泌体（MSC-Exo），为各种疾病提供了治疗机会。MSCs 和 MSC-Exos 具有免疫调节功能；它们可被用作治疗方法，以平衡 COVID-19 患者的免疫细胞。在这篇综述中，我们讨论了 COVID-19、MSCs 和 MSC 衍生的外泌体中细胞因子风暴的基础，以及基于干细胞的 COVID-19 正在进行的临床试验的潜力。[BMB 报告 2020；53（8）：400-412]。
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