胃内注射肉毒毒素 A 是 BMI>40kg/m2 的肥胖患者的有效治疗方法：系统评价和荟萃分析。
Intragastric Botulinum Toxin A Injection Is an Effective Obesity Therapy for Patients with BMI > 40 kg/m: a Systematic Review and Meta-analysis.
机构信息
Division of Thoracic Surgery, Department of Surgery, Kaohsiung Medical University Hospital/Kaohsiung Medical University, Kaohsiung City, Taiwan.
Weight Management Center, Kaohsiung Medical University Hospital/Kaohsiung Medical University, Kaohsiung City, Taiwan.
出版信息
Obes Surg. 2020 Oct;30(10):4081-4090. doi: 10.1007/s11695-020-04842-4. Epub 2020 Jul 31.
We conducted a systematic review and meta-analysis to assess the efficacy of intragastric BTA injection in patients with obesity and morbid obesity. Five RCTs were identified. Intragastric BTA injection was no superior to saline in absolute weight loss or BMI change, but significantly lengthened the gastric emptying time (MD, 15.57; 95% CI, 8.75 to 22.38). In meta-regression analysis, the absolute weight loss was lower in the patients with high baseline BMI. In subgroup analysis, the use of BTA in absolute weight loss was significantly lower among the patients with baseline BMI more than 40 kg/m (MD, - 5.31; 95% CI, - 6.17 to - 4.45). The benefit of intragastric BTA injection in reduction of absolute weight was observed in patients with baseline BMI more than 40 kg/m.
我们进行了一项系统评价和荟萃分析，以评估胃内注射 BTA 在肥胖和病态肥胖患者中的疗效。共确定了 5 项 RCT。与生理盐水相比，胃内注射 BTA 并未在绝对体重减轻或 BMI 变化方面显示出优势，但显著延长了胃排空时间（MD，15.57；95%CI，8.75 至 22.38）。在元回归分析中，基线 BMI 较高的患者绝对体重减轻较低。在亚组分析中，基线 BMI 超过 40 kg/m 的患者中，BTA 在绝对体重减轻方面的使用明显较低（MD，-5.31；95%CI，-6.17 至-4.45）。在基线 BMI 超过 40 kg/m 的患者中观察到胃内注射 BTA 减少绝对体重的益处。
Zotero 插件