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肌肉注射拟除虫菊酯与有机磷(氯氰菊酯3% + 喹硫磷20%)混合中毒,其临床表现及处理

Intramuscular pyrethroid with organophosphorus (cypermethrine 3% + quinolphos 20%) mixed poisoning, its clinical presentation and management.

作者信息

Nizami Mohammad Firoz, Sharma Chandra B, Singh Bhoopendra, Guria Rishi T

机构信息

Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

Department of Forensic Medicine and Toxicology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

出版信息

J Family Med Prim Care. 2020 May 31;9(5):2521-2523. doi: 10.4103/jfmpc.jfmpc_16_20. eCollection 2020 May.

Abstract

Organophosphorus compounds are absorbed by any route including intramuscular injection. Pyrethroid compounds are less toxic for human but in combination with organophosphates, its toxic effect potentiates due to inhibition of its metabolism. In this case report, a 40-year-old female patient presented with acute onset of pain abdomen, recurrent vomiting, and excessive salivation followed by altered mental status, on evaluation her clinical findings were suggestive of organophosphorus poisoning. Her treatment was started with injection atropine, anti-emetics, and adequate parenteral rehydration. After regaining consciousness, the patient confessed that she had taken herself intramuscular injection of pesticide which contained 3% cypermethrine plus 20% quinolphos. It was further confirmed by a very low level of plasma cholinesterase level. Intramuscular injection acted as a depot that leads to prolong intoxication and in the due course of illness, she also developed delayed onset intermediate syndrome that was managed appropriately.

摘要

有机磷化合物可通过包括肌肉注射在内的任何途径被吸收。拟除虫菊酯类化合物对人体毒性较小,但与有机磷结合时,由于其代谢受到抑制,其毒性作用会增强。在本病例报告中,一名40岁女性患者出现急性腹痛、反复呕吐和过度流涎,随后出现精神状态改变,经评估其临床症状提示有机磷中毒。她的治疗从注射阿托品、止吐药和充分的胃肠外补液开始。意识恢复后,患者承认她给自己肌肉注射了含有3%氯氰菊酯加20%喹硫磷的杀虫剂。血浆胆碱酯酶水平极低进一步证实了这一点。肌肉注射起到了储存库的作用,导致中毒时间延长,在病程中,她还出现了延迟性中间综合征,并得到了适当的处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0553/7380745/b19a640ca070/JFMPC-9-2521-g001.jpg

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