接受维生素D口服补充治疗的患者眼表的临床结局
Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement.
作者信息
Karaca Emine Esra, Kemer Özlem Evren, Özek Dilay, Berker Dilek, Imga Narin Nasiroglu
机构信息
Department of Ophthalmology, Health Sciences University, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Department of Endocrinology and Metabolism, Health Sciences University, Ankara Numune Training and Research Hospital, Ankara, Turkey.
出版信息
Arq Bras Oftalmol. 2020 Aug;83(4):312-317. doi: 10.5935/0004-2749.20200043. Epub 2020 Jul 29.
PURPOSE
To analyze the clinical outcomes of the ocular surface in patients with vitamin D deficiency after oral replacement.
METHODS
A total of 40 patients with vitamin D deficiency were enrolled in the study. The patients received 50,000 units of oral vitamin D weekly over a period of 8 weeks. After 8 weeks, 1,500-2,000 units/d were administered for 24 weeks. Eyelid margin score, meibomian gland expressibility score, Oxford grading, Schirmer I test, tear breakup time, tear osmolarity, and the Ocular Surface Disease Index score were evaluated at baseline, and at 8, 12, and 24 weeks.
RESULTS
The meibomian gland expressibility score, Schirmer I, tear breakup time, tear osmolarity, and Ocular Surface Disease Index score showed improvement 8 weeks after vitamin D supplementation (p<0.05). Compared with the pretreatment values, the eyelid margin score and Oxford grading were decreased at week 12 (p<0.05).
CONCLUSION
Vitamin D replacement appears to improve ocular surface in individuals with vitamin D deficiency.
目的
分析口服补充维生素D后维生素D缺乏患者眼表的临床结局。
方法
本研究共纳入40例维生素D缺乏患者。患者每周口服50,000单位维生素D，持续8周。8周后，每天给予1,500 - 2,000单位，持续24周。在基线、8周、12周和24周时评估睑缘评分、睑板腺可挤压性评分、牛津分级、Schirmer I试验、泪膜破裂时间、泪液渗透压和眼表疾病指数评分。
结果
补充维生素D 8周后，睑板腺可挤压性评分、Schirmer I试验、泪膜破裂时间、泪液渗透压和眼表疾病指数评分均有改善（p<0.05）。与治疗前值相比，12周时睑缘评分和牛津分级降低（p<0.05）。
结论
补充维生素D似乎可改善维生素D缺乏个体的眼表情况。
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