重塑m6A修饰在癌症转录组中的作用：综述
Reshaping the role of m6A modification in cancer transcriptome: a review.
作者信息
Yang Guanqun, Sun Zhigang, Zhang Nan
机构信息
Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, 250013 Shandong China.
Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, 250013 Shandong China.
出版信息
Cancer Cell Int. 2020 Jul 29;20:353. doi: 10.1186/s12935-020-01445-y. eCollection 2020.
N6-methyl-adenosine(m6A) modification emerges as an abundant and dynamic regulation throughout the Eukaryotic transcriptome. Dysregulation of the m6A regulators has increasingly been found in many neoplasms. It is reasonable to believe that m6A changes the fate of cancer cells and subsequently affected all aspects of cancer progression. In view of the context-dependent role of m6A modification, we emphasize a dual effect of m6A in a particular tumor model, that is, m6A plays a promoting role or a suppressing role in different stages of cancer. This novel sight is compared to the older view that a particular m6A regulator acts as a consistent role in cancer progression.
N6-甲基腺苷（m6A）修饰是真核转录组中一种丰富且动态的调控方式。在许多肿瘤中，越来越多地发现m6A调节因子失调。有理由相信，m6A改变癌细胞的命运，进而影响癌症进展的各个方面。鉴于m6A修饰的上下文依赖性作用，我们强调m6A在特定肿瘤模型中的双重作用，即在癌症的不同阶段，m6A发挥促进作用或抑制作用。这一新观点与以往认为特定m6A调节因子在癌症进展中起一致作用的观点形成对比。
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