基于晶体分析仪的X射线暗场成像中对比度和空间分辨率的提升：理论考量与实验验证
Improving contrast and spatial resolution in crystal analyzer-based x-ray dark-field imaging: Theoretical considerations and experimental demonstration.
作者信息
Ando Masami, Nakao Yuki, Jin Ge, Sugiyama Hiroshi, Sunaguchi Naoki, Sung Yongjin, Suzuki Yoshifumi, Sun Yong, Tanimoto Michio, Kawashima Katsuhiro, Yuasa Tetsuya, Mori Kensaku, Ichihara Shu, Gupta Rajiv
机构信息
Photon Factory, KEK, Oho 1-1, Tsukuba, Ibaraki, 305-0801, Japan.
Research Institute of Science and Engineering, Tokyo University of Science, Noda, Chiba, 278-8510, Japan.
出版信息
Med Phys. 2020 Nov;47(11):5505-5513. doi: 10.1002/mp.14442. Epub 2020 Oct 7.
PURPOSE
This paper describes and experimentally validates a methodology for improving contrast and spatial resolution of the x-ray dark-field imaging (XDFI) by cutting the monochromator-collimator asymmetrically and thinning the Laue angle analyzer.
METHODS
We measure the spatial resolution of our XDFI setup using a test object consisting of wolfram tungsten meshes and compare it with the theoretical prediction. Using x-ray dark-field computed tomography of breast cancer specimens (lobular carcinoma in situ), we demonstrate that the resolution of XDFI is sufficient for histopathologic analysis.
RESULTS
Our experimental results show that the overall spatial resolution of XDFI can be improved by approximately a factor of 2 when these modifications are implemented. The reconstructed images of breast cancer specimens provide sufficient details for radiologic histopathology.
CONCLUSIONS
By cutting the monochromator-collimator and thinning the Laue angle analyzer, XDFI can achieve the resolution sufficient for radiologic histopathology.
目的
本文描述并通过实验验证了一种通过不对称切割单色仪 - 准直器以及变薄劳厄角分析仪来提高X射线暗场成像（XDFI）对比度和空间分辨率的方法。
方法
我们使用由钨丝网组成的测试物体测量XDFI装置的空间分辨率，并将其与理论预测进行比较。通过对乳腺癌标本（原位小叶癌）进行X射线暗场计算机断层扫描，我们证明了XDFI的分辨率足以进行组织病理学分析。
结果
我们的实验结果表明，实施这些改进后，XDFI的整体空间分辨率可提高约2倍。乳腺癌标本的重建图像为放射组织病理学提供了足够的细节。
结论
通过切割单色仪 - 准直器和变薄劳厄角分析仪，XDFI可以实现足以进行放射组织病理学的分辨率。
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