青少年晚期结肠腺癌：2例报告
Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases.
作者信息
Vundamati Divya S, Chen Xiuxu, Singh Vivekanand
机构信息
University of Missouri School of Medicine, Kansas City, MO 64108, USA.
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
出版信息
Case Rep Pathol. 2020 Jul 28;2020:1848367. doi: 10.1155/2020/1848367. eCollection 2020.
BACKGROUND
Carcinoma of colon is rare in children and adolescents. The staging criteria of the carcinoma is the same as those for adults. However, the pathogenetic background in pediatric cases is different from adults and usually involves mismatch repair gene mutations or familial polyposis syndromes. . We describe two adolescents diagnosed with advanced stage colon carcinoma and discuss the histological appearance, testing for mismatch repair genes and contrast- it with carcinoma occurring in the setting of familial polyposis syndrome.
CONCLUSION
Colonic carcinoma occurring in pediatric patients should prompt a work-up for mismatch repair gene mutation status. Despite higher stage of presentation, some of the pediatric patients may respond favorably to chemotherapy and surgical resection.
背景
结肠癌在儿童和青少年中较为罕见。其分期标准与成人相同。然而，儿科病例的发病机制背景与成人不同，通常涉及错配修复基因突变或家族性息肉病综合征。我们描述了两名被诊断为晚期结肠癌的青少年，并讨论了其组织学表现、错配修复基因检测，并将其与家族性息肉病综合征背景下发生的癌进行对比。
结论
儿科患者发生的结肠癌应促使对其错配修复基因突变状态进行检查。尽管就诊时分期较高，但部分儿科患者可能对化疗和手术切除反应良好。
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