查佩纳：连接古老的 RNA 和蛋白质世界。
Chaperna: linking the ancient RNA and protein worlds.
作者信息
Son Ahyun, Horowitz Scott, Seong Baik L
机构信息
Department of Chemistry & Biochemistry, Knoebel Institute for Healthy Aging, University of Denver , Denver, CO, USA.
Department of Biotechnology, College of Bioscience and Biotechnology, Yonsei University , Seoul, Korea.
出版信息
RNA Biol. 2021 Jan;18(1):16-23. doi: 10.1080/15476286.2020.1801199. Epub 2020 Aug 11.
Abstract
As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with proteins of biological relevance. The ribozyme-resident protein folding activity, even before the advent of protein-based molecular chaperone, must have expedited the transition of the RNA world into the present protein theatre.
摘要
作为自我复制生物形式转变的精神框架，RNA 世界概念规定了 RNA 作为遗传物质和催化剂的双重功能。在涉及蛋白质合成和 tRNA 成熟的核酶中发现了伴侣功能，使与生物学相关的蛋白质丰富了原始的 RNA 世界。核酶固有的蛋白质折叠活性，甚至在基于蛋白质的分子伴侣出现之前，就必须加速 RNA 世界向现在的蛋白质舞台的转变。
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