Department of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, E-08921 Santa Coloma de Gramenet, Spain.
Institute of Nutrition and Food Safety of the University of Barcelona (INSA-UB), E-08921 Santa Coloma de Gramenet, Spain.
Nutrients. 2020 Aug 10;12(8):2393. doi: 10.3390/nu12082393.
The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.
肥胖的预防和治疗主要基于健康生活方式的随访，其中包括健康饮食，重要的是含有生物活性化合物，如多酚。多年来，多酚的健康益处归因于它们作为自由基清除剂的抗氧化能力。最近有研究描述，多酚激活了其他与 ROS 产生无关但与代谢调节有关的细胞信号通路。在这篇综述中，我们通过关注类黄酮的代谢作用，总结了该领域的现有知识。类黄酮广泛分布于植物界，用于生长和防御。它们的结构特征是两个苯环和一个杂环吡喃环，根据杂环的氧化和饱和度状态，类黄酮分为七个不同的亚类。本工作重点描述了类黄酮在肥胖和肥胖相关疾病中的代谢作用的分子机制。我们描述了每一组类黄酮在肝脏、白色和棕色脂肪组织以及中枢神经系统中的作用，以及涉及的代谢和信号通路。
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