University Hospitals Centre for Health Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Prog Cardiovasc Dis. 2020 Nov-Dec;63(6):792-799. doi: 10.1016/j.pcad.2020.08.002. Epub 2020 Aug 12.
To examine the exercise intensity and impact of 12 months of twice-weekly recreational football training on cardiorespiratory fitness (CRF), blood pressure (BP), resting heart rate (HR), body fat mass, blood lipids, inflammation, and health-related quality of life in women treated for early-stage breast cancer (BC).
Sixty-eight women who had received surgery for stage I-III BC and completed adjuvant chemo- and/or radiation therapy within 5 years were randomized in a 2:1 ratio to a Football Fitness group (FFG, n = 46) or a control group (CON, n = 22). Football Fitness sessions comprised a warm-up, drills and 3-4 × 7 min of small-sided games (SSG). Assessments were performed at baseline, 6 months and 12 months. Outcomes were peak oxygen uptake (VOpeak), blood pressure (BP), HR, total body fat mass, and circulating plasma lipids and hs-CRP, and the 36-Item Short Form Health Survey (SF36). Intention-to-treat (ITT) analyses were performed using linear mixed models. Data are means with SD or 95% confidence intervals.
Adherence to training in participants completing the 12-months follow-up (n = 33) was 47.1% (22.7), and HR during SSG was ≥80% of HR for 69.8% (26.5) of total playing time. At baseline, VOpeak was 28.5 (6.4) and 25.6 (5.9) ml O/kg/min in FFG and CON, respectively, and no significant changes were observed at 6- or 12 months follow-up. Systolic BP (SBP) was 117.1 (16.4) and 116.9 (14.8) mmHg, and diastolic BP (DBP) was 72.0 (11.2) and 72.4 (8.5) mmHg in FFG and CON, respectively, at baseline, and a 9.4 mmHg decrease in SBP in CON at 12 months resulted in a between-group difference at 12 months of 8.7 mmHg (p = .012). Blood lipids and hs-CRP were within the normal range at baseline, and there were no differences in changes between groups over the 12 months. Similarly, no differences between groups were observed in HR and body fat mass at 6- and12-months follow-up. A between-group difference in mean changes of 23.5 (0.95-46.11) points in the role-physical domain of the SF36 survey favored FFG at 6 months.
Football Fitness training is an intense exercise form for women treated for breast cancer, and self-perceived health-related limitations on daily activities were improved after 6 months. However, 1 year of Football Fitness training comprising 1 weekly training session on average did not improve CRF, BP, blood lipids, fat mass, or HR.
The trial was registered at ClinicalTrials.gov with identifier NCT03284567.
探讨为期 12 个月、每周两次的休闲足球训练对接受早期乳腺癌（BC）治疗的女性的心肺功能（CRF）、血压（BP）、静息心率（HR）、体脂肪量、血脂、炎症和健康相关生活质量的影响。
68 名女性在接受 I-III 期 BC 手术后，在 5 年内完成了辅助化疗和/或放疗，按照 2:1 的比例随机分为足球健身组（FFG，n=46）或对照组（CON，n=22）。足球健身课程包括热身、训练和 3-4×7 分钟的小场比赛（SSG）。在基线、6 个月和 12 个月进行评估。结果为峰值摄氧量（VOpeak）、血压（BP）、HR、全身脂肪量和循环血浆脂质和 hs-CRP，以及 36 项简明健康调查（SF36）。采用线性混合模型进行意向治疗（ITT）分析。数据为平均值±标准差或 95%置信区间。
完成 12 个月随访的参与者（n=33）的训练依从性为 47.1%（22.7），SSG 期间的 HR 达到 HR 的 80%以上的时间占总运动时间的 69.8%（26.5）。基线时，FFG 和 CON 的 VOpeak 分别为 28.5（6.4）和 25.6（5.9）ml O/kg/min，6 个月和 12 个月随访时未见明显变化。收缩压（SBP）分别为 117.1（16.4）和 116.9（14.8）mmHg，舒张压（DBP）分别为 72.0（11.2）和 72.4（8.5）mmHg，CON 在 12 个月时 SBP 下降 9.4mmHg，导致 12 个月时组间差异为 8.7mmHg（p=0.012）。基线时血脂和 hs-CRP 均在正常范围内，12 个月内组间无变化差异。同样，6 个月和 12 个月随访时，HR 和体脂肪量在两组间无差异。SF36 调查中角色身体领域的平均变化为 23.5（0.95-46.11）分，有利于 FFG，6 个月时差异有统计学意义。
足球健身训练是一种针对乳腺癌治疗女性的剧烈运动形式，6 个月后自我感知的日常活动相关健康限制得到改善。然而，1 年的足球健身训练平均每周进行 1 次，并未改善 CRF、BP、血脂、脂肪量或 HR。
该试验在 ClinicalTrials.gov 注册，标识符为 NCT03284567。
