阿尔茨海默病内嗅皮层中潜在致病的二水草酸钙和二氧化钛晶体。
Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer's Disease Entorhinal Cortex.
机构信息
McKetta Department of Chemical Engineering and University of Texas, Austin, TX, USA.
Texas Materials Institute, University of Texas, Austin, TX, USA.
出版信息
J Alzheimers Dis. 2020;77(2):547-550. doi: 10.3233/JAD-200535.
Abstract
Knowing that Alzheimer's disease (AD) nucleates in the entorhinal cortex (EC), samples of 12 EC specimens were probed for crystals by a protocol detecting fewer than 1/5000th of those present. Of the 61 crystals found, 31 were expected and 30 were novel. Twenty-one crystals of iron oxides and 10 atherosclerosis-associated calcium pyrophosphate dihydrate crystals were expected and found. The 30 unexpected crystals were NLRP3-inflammasome activating calcium oxalate dihydrate (12) and titanium dioxide (18). Their unusual distribution raises the possibility that some were of AD origination sites.
摘要
已知阿尔茨海默病（AD）在海马旁回（EC）中形成核，通过检测不到现有晶体 1/5000 的方案对 12 个 EC 标本进行了晶体探测。在发现的 61 个晶体中，31 个是预期的，30 个是新的。发现了 21 个氧化铁晶体和 10 个与动脉粥样硬化相关的焦磷酸钙二水合物晶体。预期和发现的 30 个意外晶体是 NLRP3-炎症小体激活的草酸钙二水合物（12）和二氧化钛（18）。它们的异常分布提出了这样一种可能性，即其中一些可能来自 AD 起源部位。
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