Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou, Guangdong, China.
Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital , Harbin, Heilongjiang, China.
Cell Cycle. 2020 Sep;19(18):2367-2372. doi: 10.1080/15384101.2020.1808382. Epub 2020 Aug 18.
Recent studies have revealed that long non-coding RNAs (lncRNAs) play critical roles in the tumorigenesis and proliferation of human cancer. Several polymorphisms of lncRNAs have been found to be involved in the risk of neuroblastoma (NB). However, studies on the relationship between polymorphisms in lncRNA exons and NB are infrequent. We evaluated the association between rs11752942 A > G polymorphism in exon and neuroblastoma susceptibility by performing a hospital-based study with 275 patients and 531 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) assessed by using logistic regression models were used to determine the strength of the association. We found that the rs11752942 G allele is significantly associated with decreased neuroblastoma risk (AG vs. AA: adjusted OR = 0.72, 95% CI = 0.53-0.98, = 0.038; and AG/GG vs. AA: adjusted OR = 0.74, 95% CI = 0.55-0.99, = 0.045) after adjusting for age and gender. This association was more prominent in females, subjects with tumor in the mediastinum or early-stage. Furthermore, the expression quantitative trait locus analysis indicated that rs11752942 G was associated with decreased expression of its neighboring gene mRNA. These results indicate that may be a novel potentially functional lncRNA that may be used as a predictive marker, for it might contribute to decreased neuroblastoma risk.
最近的研究表明，长非编码 RNA（lncRNA）在人类癌症的发生和增殖中起着关键作用。已经发现几种 lncRNA 多态性与神经母细胞瘤（NB）的风险有关。然而，关于 lncRNA 外显子多态性与 NB 之间关系的研究并不常见。我们通过对 275 例患者和 531 例对照进行基于医院的研究，评估了 lncRNA 外显子 rs11752942A > G 多态性与神经母细胞瘤易感性之间的关系。使用逻辑回归模型评估的比值比（OR）和 95％置信区间（CI）用于确定关联的强度。我们发现，rs11752942 G 等位基因与神经母细胞瘤风险降低显著相关（AG 与 AA：调整后的 OR = 0.72，95％CI = 0.53-0.98， = 0.038；AG/GG 与 AA：调整后的 OR = 0.74，95％CI = 0.55-0.99， = 0.045），调整了年龄和性别因素。这种关联在女性、纵隔肿瘤或早期肿瘤患者中更为明显。此外，表达数量性状基因座分析表明，rs11752942G 与邻近基因 mRNA 的表达降低有关。这些结果表明，可能是一种新的潜在功能 lncRNA，可作为预测标志物，因为它可能有助于降低神经母细胞瘤的风险。
