University College Cork School of Medicine, Cork, Ireland.
Department of Rheumatology, Cork University Hospital, Cork, Ireland.
Ir Med J. 2020 Mar 13;113(3):36.
Aim Studies indicate that <50% of polymyalgia rheumatica (PMR) patients receive bone protective therapy (BPT) forglucocorticoid-induced osteoporosis (GIOP) prevention. We sought to determine if PMR patients are protected fromGIOP by examining bone densitometry (DXA) scan results, BPT use, and adherence to guidelines. Methods PMR patients treated with glucocorticoids who underwent a DXA scan at Cork University Hospital from 01/01/2016 to27/10/2017 were included. Patient data were obtained from chart review. Results Out of 153 patients, 73 (47.7%) were taking BPT and 42 (27.5%) were not. At the most recent DXA scan, 42 (27.5%) had normal BMD, 84 (54.9%) were osteopaenic, and 27 (17.6%) were osteoporotic. In 91 individuals who underwent≥2 DXA scans, patients not receiving bisphosphonates were more likely to have BMD loss over time (p=0.022). Discussion Despite recommendations, many patients are not prescribed BPT. The results suggest that PMR patients in Cork arenot optimally protected from GIOP.
研究表明,<50%的巨细胞动脉炎(PMR)患者接受骨保护治疗(BPT)以预防糖皮质激素诱导的骨质疏松症(GIOP)。我们试图通过检查骨密度(DXA)扫描结果、BPT 使用情况以及对指南的遵循情况来确定 PMR 患者是否能免受 GIOP 的影响。
纳入了 2016 年 1 月 1 日至 2017 年 10 月 27 日期间在科克大学医院接受糖皮质激素治疗且进行 DXA 扫描的 PMR 患者。通过病历回顾获取患者数据。
在 153 名患者中,73 名(47.7%)正在接受 BPT,42 名(27.5%)未接受 BPT。在最近的 DXA 扫描中,42 名(27.5%)的骨密度正常,84 名(54.9%)为骨质疏松,27 名(17.6%)为骨质疏松症。在 91 名进行了≥2 次 DXA 扫描的患者中,未服用双膦酸盐的患者的骨密度随时间推移丢失的可能性更大(p=0.022)。
尽管有建议,但许多患者并未开具 BPT 处方。结果表明,科克的 PMR 患者并未得到 GIOP 的最佳保护。