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扩展迟发性综合征的现象学异质性:是时候进行更新的评估工具了。

Expanding phenomenologic heterogeneity of tardive syndromes: Time for an updated assessment tool.

机构信息

Chulalongkorn Center of Excellence for Parkinson's Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand.

The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry and Molecular Medicine, Hempstead, NY, USA; The Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY, USA; The Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, NY, USA.

出版信息

Parkinsonism Relat Disord. 2020 Aug;77:141-145. doi: 10.1016/j.parkreldis.2020.06.023. Epub 2020 Jun 30.

Abstract

Tardive syndromes (TDS) are a group of hyperkinetic and hypokinetic movement disorders that occurs after exposure to dopamine receptor blocking agents such as antipsychotic and antiemetic drugs. The Abnormal Involuntary Movement Scale (AIMS) is a widely used instrument that has become the standard for assessment of tardive dyskinesia (TDD), the most common form of TDS. However, the AIMS has a number of clinimetric limitations and was designed primarily to assess the anatomic distribution and severity of involuntary movements without regard to phenomenology. To build on recent advances in understanding and treatment of TDS, re-evaluation and revision of the AIMS that could aid both clinical practice and research may be worthwhile. Challenges, such as retaining the efficiency of the current AIMS, incorporating evaluation of impairment in daily activities, and re-training clinicians for a revised examination procedure and rating instrument, are very likely surmountable.

摘要

迟发性运动障碍(TDS)是一组在接触多巴胺受体阻滞剂(如抗精神病药和止吐药)后发生的运动障碍,包括运动过多和过少。异常不自主运动量表(AIMS)是一种广泛使用的工具,已成为评估迟发性运动障碍(TDD)的标准,TDD 是 TDS 最常见的形式。然而,AIMS 存在许多临床限制,主要用于评估不自主运动的解剖分布和严重程度,而不考虑其表现。为了在理解和治疗 TDS 方面取得新的进展,重新评估和修订 AIMS,这可能有助于临床实践和研究,可能是值得的。挑战,如保持当前 AIMS 的效率,纳入对日常活动中受损的评估,以及为修订后的检查程序和评分工具对临床医生进行再培训,很可能是可以克服的。

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