Miller-Breslow A, Dorfman H D
Department of Orthopaedic Surgery, Montefiore Medical Center, Bronx, New York 10467-2490.
Am J Surg Pathol. 1988 May;12(5):368-78. doi: 10.1097/00000478-198805000-00005.
Because it may produce a bewildering array of histologic patterns, the clinical entity of subungual exostosis (Dupuytren's exostosis), is sometimes confused with chondrosarcoma. However, this lesion is a distinct entity. It begins as a reactive growth of cellular fibrous tissue and metaplastic cartilage, which undergoes enchondral ossification. The rate of growth may be exuberant, but it is limited. We present a series of 15 cases as well as a review of the literature. Postadolescents and young adults are most commonly affected, and the majority of cases (80%) occur on the dorsal-medial aspect of the great toe. Trauma, whether chronic or acute, and infection are frequent inciting factors. The radiologic picture is consistent and can be diagnostic. In more than half our cases, chondrosarcoma was suspected initially. However, if the entire clinical picture is evaluated, the histologic findings should not lead to confusion with a malignant process. This acquired exostosis is benign; local excision is curative. However, recurrence is common (53%) after incomplete excision or when the lesion has not achieved full maturation.
由于甲下外生骨疣(Dupuytren外生骨疣)的临床实体可能会产生一系列令人困惑的组织学模式,有时会与软骨肉瘤混淆。然而,这种病变是一种独特的实体。它开始于细胞性纤维组织和化生软骨的反应性生长,随后经历软骨内骨化。其生长速度可能很快,但却是有限的。我们展示了一系列15例病例,并对文献进行了综述。青少年后期和年轻人最常受影响,大多数病例(80%)发生在拇趾的背内侧。创伤,无论是慢性还是急性的,以及感染都是常见的诱发因素。影像学表现是一致的,具有诊断价值。在我们超过半数的病例中,最初怀疑为软骨肉瘤。然而,如果对整个临床情况进行评估,组织学结果不应导致与恶性病变混淆。这种后天性外生骨疣是良性的;局部切除可治愈。然而,不完全切除后或病变尚未完全成熟时,复发很常见(53%)。