PAX-8在苏丹被诊断为女性生殖道恶性肿瘤患者中的免疫组化表达。

Immunohistochemical expression of PAX-8 in Sudanese patients diagnosed with malignant female reproductive tract tumors.

作者信息

Ali Eman T, Mohamed Nouh S, Shafig Irene R, Muneer Mohamed S, Yosif Abubaker Ahmed, Hassan Lamis Ahmed, Mohamed Areeg M, Ahmed Ayman, Siddig Emmanuel E

机构信息

Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.

Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, National University, Khartoum, Sudan.

出版信息

BMC Res Notes. 2020 Aug 26;13(1):396. doi: 10.1186/s13104-020-05246-4.

DOI:10.1186/s13104-020-05246-4

PMID:32847623

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7449036/

Abstract

OBJECTIVES

Paired box protein-8 (PAX-8) immunohistochemical expression can be used as a diagnostic marker for epithelial cells tumors. This study aimed at investigating the immunohistochemical expression of PAX-8 among Sudanese females diagnosed with cervical, endometrial, and ovarian cancers between December 2017 and May 2019 by studying their Formalin-fixed paraffin embedded blocks.

RESULTS

Sixty patients diagnosed with female reproductive tract cancers were included who aged 58.7 ± 6.9 years (range, 43-71). Cervix was the most common cancer site in 51/60 (85%) patients. Regarding cancer stage, there was 17 (28%) and 14 (23%) of the study population had stage 3B and 2B, respectively. The histopathological diagnosis included 20 (44%), 13 (29%), and 12 (27%) poorly, moderately, and well differentiated cervical squamous cell carcinoma (SCC) as well as 11 (73%), 2 (13%), 1 (7%), and 1 (7%) endometrial adenocarcinoma, metastatic adenocarcinoma, endocervical adenocarcinoma, and ovarian mucinous cyst adenocarcinoma, respectively. PAX-8 was positively expressed in 9 endometrial adenocarcinoma, 1 endocervical adenocarcinoma and 1 ovarian mucinous cyst adenocarcinoma, 2 poorly, and 1 moderately differentiated SCC. All patients diagnosed with well differentiated SCC and metastatic adenocarcinoma showed no expression of PAX-8. A statistically significant was seen for PAX-8 expression and the different histopathological diagnosis, P value < 0.001.

摘要

目的

配对盒蛋白8（PAX-8）免疫组化表达可作为上皮细胞肿瘤的诊断标志物。本研究旨在通过研究2017年12月至2019年5月期间诊断为宫颈癌、子宫内膜癌和卵巢癌的苏丹女性患者的福尔马林固定石蜡包埋块，调查PAX-8的免疫组化表达情况。

结果

纳入60例诊断为女性生殖道癌症的患者，年龄58.7±6.9岁（范围43 - 71岁）。宫颈是最常见的癌症部位，占51/60（85%）的患者。关于癌症分期，研究人群中分别有17例（28%）和14例（23%）处于3B期和2B期。组织病理学诊断包括20例（44%）、13例（29%）和12例（27%）低分化、中分化和高分化宫颈鳞状细胞癌（SCC），以及11例（73%）、2例（13%）、1例（7%）和1例（7%）子宫内膜腺癌、转移性腺癌、宫颈管腺癌和卵巢黏液性囊腺癌。PAX-8在9例子宫内膜腺癌、1例宫颈管腺癌、1例卵巢黏液性囊腺癌、2例低分化和1例中分化SCC中呈阳性表达。所有诊断为高分化SCC和转移性腺癌的患者均未显示PAX-8表达。PAX-8表达与不同组织病理学诊断之间存在统计学显著差异，P值<0.001。