细胞因子风暴释放综合征与 COVID-19 的免疫治疗前景，第 4 部分：JAK 抑制的作用
Cytokine storm release syndrome and the prospects for immunotherapy with COVID-19, part 4: The role of JAK inhibition.
作者信息
Calabrese Leonard H, Lenfant Tiphaine, Calabrese Cassandra
机构信息
Department of Rheumatic and Immunologic Diseases, Orthopedic & Rheumatologic Institute, Cleveland Clinic
Department of Rheumatic and Immunologic Diseases, Orthopedic & Rheumatologic Institute Department of Infectious Disease, Cleveland Clinic.
出版信息
Cleve Clin J Med. 2021 Mar 1. doi: 10.3949/ccjm.87a.ccc060.
This review focuses on an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cytokines and mediators.
本综述聚焦于一种利用小分子抑制关键信号转导通路——Janus激酶-信号转导子和转录激活子（JAK-STAT）信号通路的替代策略。JAK-STAT通路介导大量炎性细胞因子和介质的生物学活性。
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