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巨细胞动脉炎患者伴其他眼部诊断的视力丧失。

Vision Loss From Giant Cell Arteritis in Patients With Other Ocular Diagnoses.

机构信息

Faculty of Medicine (PN), University of Toronto, Toronto, Canada; Departments of Ophthalmology (VB, NJN), Neurology (VB, NJN), and Neurological Surgery (NJN), Emory University School of Medicine, Atlanta, Georgia; Department of Ophthalmology & Vision Sciences (JAM), University of Toronto, Toronto, Canada; and Division of Neurology (JAM), Department of Medicine, University of Toronto, Toronto, Canada.

出版信息

J Neuroophthalmol. 2021 Jun 1;41(2):e254-e258. doi: 10.1097/WNO.0000000000001064.

Abstract

Vision problems from giant cell arteritis (GCA) can be difficult to diagnose as patients may present with vision loss in the absence of systemic symptoms, have other comorbidities that affect inflammatory blood markers, or have other ocular diagnoses. We present 3 cases illustrating this point including a patient with advanced glaucoma with worsening vision from posterior ischemic optic neuropathy from GCA, a patient with arteritic anterior ischemic optic neuropathy (AAION) erroneously diagnosed as optic neuritis without elevated inflammatory blood markers due to corticosteroid use, and a patient with AAION and a history of nonarteritic anterior ischemic optic neuropathy in her fellow eye and untreated obstructive sleep apnea. GCA should be kept in the differential diagnosis for patients over 50 years of age even if they carry other ocular diagnoses. Temporal artery biopsy remains the gold standard for GCA diagnosis and is often required in equivocal cases.

摘要

巨细胞动脉炎(GCA)引起的视力问题可能难以诊断,因为患者可能在没有全身症状的情况下出现视力丧失,或者有其他影响炎症血液标志物的合并症,或者有其他眼部诊断。我们提出了 3 个病例来说明这一点,包括一例因 GCA 引起的后部缺血性视神经病变导致的晚期青光眼伴视力恶化的患者,一例因使用皮质类固醇而误诊为视神经炎但炎症血液标志物未升高的动脉炎性前部缺血性视神经病变(AAION)患者,以及一例 AAION 患者,其对侧眼有非动脉炎性前部缺血性视神经病变病史且未治疗阻塞性睡眠呼吸暂停。即使患者有其他眼部诊断,对于 50 岁以上的患者,仍应将 GCA 纳入鉴别诊断。颞动脉活检仍然是 GCA 诊断的金标准,在不确定的情况下通常需要进行。

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