Institue of Pharmacology & Toxicology, Medical Faculty Mannheim, Ruprecht-Karls-University of Heidelberg , Germany.
Hypertension Centre Munich, An Excellence Centre of the European Society of Hypertension (ESH) , München, Germany.
Chronobiol Int. 2020 Aug;37(8):1269. doi: 10.1080/07420528.2020.1812901. Epub 2020 Sep 1.
The reply of Hermida et al. (2020) to our critical comments on the MAPEC and HYGIA Lemmer and Middeke (2020) studies in this Journal is insufficient and incomplete. Hermida does not address our first and main point on the baseline blood pressure values of 131/77 mmHg over 48 hours comprising 57.4% of the treated hypertensives (according to Table 1 in HYGIA) and consequently 42.6% of the untretated hypertensives! We criticized that in the HYGIA study; both normal and treated patients were included in one group not separated by statistics and without information on the baseline blood pressure values in each subgroup. This basic failure is our key issue of criticism and the basis of unreliability concerning the whole publication. This issue was not picked up in the recent comment of Hermida et al. (2020). They just concentrated on minor points in order to reject our severe criticism.
Hermida 等人(2020 年)对我们在本刊上对 MAPEC 和 HYGIA(Lemmer 和 Middeke,2020 年)研究的批评性评论的回复是不充分和不完整的。Hermida 没有回应我们的第一点和主要观点,即 48 小时内的基础血压值为 131/77mmHg,其中 57.4%的高血压患者接受了治疗(根据 HYGIA 表 1),因此,42.6%的高血压患者未接受治疗!我们批评说,在 HYGIA 研究中;正常和治疗患者被包含在一个组中,没有通过统计学进行分离,也没有每个亚组的基础血压值信息。这一基本错误是我们批评的关键问题,也是整个出版物不可靠的基础。Hermida 等人(2020 年)最近的评论没有提到这个问题。他们只是集中在一些次要问题上,以否定我们的严厉批评。