哈维氏弧菌群体感应作为药物发现靶点的当前进展

Current advances in Vibrio harveyi quorum sensing as drug discovery targets.

作者信息

Chen Jianwei, Lu Yaojia, Ye Xinyi, Emam Mahmoud, Zhang Huawei, Wang Hong

机构信息

College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, China.

College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, China; Phytochemistry and Plant Systematics Department, National Research Centre, 33 El Bohouth St., Dokki, Giza, 12622, Egypt.

出版信息

Eur J Med Chem. 2020 Dec 1;207:112741. doi: 10.1016/j.ejmech.2020.112741. Epub 2020 Aug 17.

DOI:10.1016/j.ejmech.2020.112741

PMID:32871343

Abstract

Vibrio harveyi is a marine bacterial pathogen which infects a wide range of marine organisms and results in severe loss. Antibiotics have been used for prophylaxis and treatment of V. harveyi infection. However, antibiotic resistance is a major public health threat to both human and animals. Therefore, there is an urgent need for novel antimicrobial agents with new modes of action. In V. harveyi, many virulence factors production and bioluminescence formation depend on its quorum sensing (QS) network. Therefore, the QS system has been widely investigated as an effective potential target for the treatment of V. harveyi infection. This perspective focuses on the quorum sensing inhibitors (QSIs) of V. harveyi QS systems (LuxM/N, LuxS/PQ, and CqsA/S) and evaluates medicinal chemistry strategies.

摘要

哈维氏弧菌是一种海洋细菌病原体，可感染多种海洋生物并导致严重损失。抗生素已被用于预防和治疗哈维氏弧菌感染。然而，抗生素耐药性对人类和动物来说都是一个重大的公共卫生威胁。因此，迫切需要具有新作用模式的新型抗菌剂。在哈维氏弧菌中，许多毒力因子的产生和生物发光的形成都依赖于其群体感应（QS）网络。因此，QS系统作为治疗哈维氏弧菌感染的有效潜在靶点已被广泛研究。这篇综述聚焦于哈维氏弧菌QS系统（LuxM/N、LuxS/PQ和CqsA/S）的群体感应抑制剂（QSIs），并评估药物化学策略。