Brazilian Species: Antifungal Activity against Clinically Relevant Species, Cellular Target, and In Vivo Toxicity.

Plants belonging to the genus are widely used in Brazil due to their antimicrobial properties, among others. The re-emergence of classic fungal diseases as a consequence of antifungal resistance to available drugs has stimulated the search for plant-based compounds with antifungal activity, especially against . The -infected model was used to evaluate the in vitro antifungal potential of leaf extracts and trunk oleoresins against species. The leaf extracts exhibited good antifungal activity against all species, with MIC values ranging from 5.86 to 93.75 µg/mL. Both the and leaf extracts at 46.87 µg/mL inhibited biofilm formation and showed no toxicity to The survival of -infected nematodes increased at all the tested extract concentrations. Exposure to leaf extracts markedly increased cell vacuolization and cell membrane damage. Therefore, leaf extracts are potential candidates for the development of new and safe antifungal agents.