Terpstra Chantal, Scholey Andrew, Verster Joris C, Benson Sarah
Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia.
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The Netherlands.
J Clin Med. 2020 Aug 31;9(9):2823. doi: 10.3390/jcm9092823.
Hangover resistance may be linked to an increased risk of continuing harmful drinking behaviours as well as involvement in potentially dangerous daily activities such as driving while hungover, mainly due to the absence of negative consequences (i.e., hangover symptoms) the day after alcohol consumption. The aim of this study was to examine the occurrence of claimed alcohol hangover resistance relative to estimated blood alcohol concentration (eBAC). A total of 1198 participants completed an online survey by answering questions regarding their demographics, alcohol consumption and occurrence of hangover. Two methods were used to calculate eBAC, one based on the modified Widmark Equation (N = 955) and the other from an equation averaging the total body water (TBW) estimates of Forrest, Watson, Seidl, Widmark and Ulrich (males only) (N = 942). The percentage of participants who claimed to be hangover resistant decreased rapidly with increasing eBAC and only a small number of hangover resistant drinkers remained at higher eBACs. Comparisons of the eBACs calculated by the two methods revealed significantly higher BACs when using the modified Widmark equation. These findings suggest that additional research for eBAC calculations is needed to improve accuracy and comprehensiveness of these equations for future alcohol hangover research.
抗宿醉可能与持续有害饮酒行为的风险增加以及参与潜在危险的日常活动(如宿醉时开车)有关,主要是因为饮酒后第二天没有负面后果(即宿醉症状)。本研究的目的是检查相对于估计的血液酒精浓度(eBAC),声称具有抗酒精宿醉能力的情况。共有1198名参与者通过回答有关其人口统计学、饮酒情况和宿醉发生情况的问题完成了一项在线调查。使用两种方法计算eBAC,一种基于修正的维德马克方程(N = 955),另一种基于福雷斯特、沃森、赛德尔、维德马克和乌尔里希(仅适用于男性)的总体水(TBW)估计值平均方程(N = 942)。声称具有抗宿醉能力的参与者比例随着eBAC的增加而迅速下降,只有少数抗宿醉饮酒者在较高的eBAC水平下仍保持该能力。两种方法计算出的eBAC比较显示,使用修正的维德马克方程时BAC显著更高。这些发现表明,需要对eBAC计算进行更多研究,以提高这些方程在未来酒精宿醉研究中的准确性和全面性。