SNHG1 通过调控 miR-3127-5p/FZD4/Wnt/β-catenin 信号通路抑制黄芩素在宫颈癌中的抑癌作用。
SNHG1 represses the anti-cancer roles of baicalein in cervical cancer through regulating miR-3127-5p/FZD4/Wnt/β-catenin signaling.
机构信息
Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Sichuan 610041, China.
Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Sichuan 610041, China.
出版信息
Exp Biol Med (Maywood). 2021 Jan;246(1):20-30. doi: 10.1177/1535370220955139. Epub 2020 Sep 3.
Baicalein exhibits anti-cancer roles in several cancers. However, the factors influencing the antitumorigenic efficiencies of baicalein in CC remain largely unclear. Here, we provide convincing evidences that lncRNA SNHG1 attenuates the tumor-suppressive roles of baicalein in CC cell viability, apoptosis, migration, and CC tumor growth. This study further demonstrates that the influences of SNHG1 in the antitumorigenic process of baicalein are achieved through modulating the miR-3127-5p/FZD4Wnt/β-catenin axis. SNHG1 attenuates the repressive role of baicalein on Wnt/β-catenin. Therefore, SNHG1 is a novel modulator of the tumor-suppressive roles of baicalein and SNHG1 represents a therapeutic intervention target to reinforce the tumor-suppressive roles of baicalein in CC.
黄芩素在几种癌症中表现出抗癌作用。然而，影响黄芩素在 CC 中抗肿瘤效率的因素在很大程度上尚不清楚。在这里，我们提供了令人信服的证据表明，lncRNA SNHG1 减弱了黄芩素对 CC 细胞活力、细胞凋亡、迁移和 CC 肿瘤生长的肿瘤抑制作用。这项研究进一步表明，SNHG1 在黄芩素抗肿瘤过程中的影响是通过调节 miR-3127-5p/FZD4Wnt/β-catenin 轴实现的。SNHG1 减弱了黄芩素对 Wnt/β-catenin 的抑制作用。因此，SNHG1 是黄芩素肿瘤抑制作用的新型调节剂，SNHG1 代表了增强黄芩素在 CC 中肿瘤抑制作用的治疗干预靶点。
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