BARMR1/FAM92A1，一个具有多种功能的 BAR 结构域蛋白编码的新基因。

BARMR1/FAM92A1, a novel gene encoding BAR domain protein with multi-functions.

机构信息

HubeiKeyLaboratoryof Embryonic Stem Cell Research, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.

出版信息

Gene. 2021 Jan 10;765:145074. doi: 10.1016/j.gene.2020.145074. Epub 2020 Sep 3.

DOI:10.1016/j.gene.2020.145074

PMID:32891772

Abstract

BARMR1/FAM92A1 encodes a novel BAR domain protein, and is widely expressed during embryonic development and highly expressed in tumor cells. Mutation or deletion of BARMR1/FAM92A1 caused developmental disorder and the BARMR1/FAM92A1 overexpression in tumor cells is associated with poor prognosis. The subcellular location of BARMR1/FAM92A1 determined its biological functions by interacting with different proteins. When colocalized and interacted with CBY at the centrioles/basal bodies of primary cilia, BARMR1/FAM92A1 facilitate ciliogenesis, whilst binded to GAL1 in the nuclei, it promotes cell proliferation, migration, and malignancy of tumor cells.

摘要

BARMR1/FAM92A1 编码一种新型 BAR 结构域蛋白，在胚胎发育过程中广泛表达，并在肿瘤细胞中高表达。BARMR1/FAM92A1 的突变或缺失会导致发育障碍，而肿瘤细胞中 BARMR1/FAM92A1 的过表达与预后不良有关。BARMR1/FAM92A1 的亚细胞定位通过与不同的蛋白质相互作用决定了其生物学功能。当与初级纤毛中心粒/基体的 CBY 共定位和相互作用时，BARMR1/FAM92A1 促进纤毛发生，而与核内的 GAL1 结合时，它促进肿瘤细胞的增殖、迁移和恶性转化。