National Centre for Radiation Research & Technology, Egyptian Atomic Energy Authority, Ahmed El-Zomor St. 3, El-Zohoor Dist., Nasr City, Cairo 11765, Egypt.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
Mar Drugs. 2020 Sep 4;18(9):457. doi: 10.3390/md18090457.
Marine natural products have achieved great success as an important source of new lead compounds for drug discovery. The Red Sea provides enormous diversity on the biological scale in all domains of life including micro- and macro-organisms. In this review, which covers the literature to the end of 2019, we summarize the diversity of bioactive secondary metabolites derived from Red Sea micro- and macro-organisms, and discuss their biological potential whenever applicable. Moreover, the diversity of the Red Sea organisms is highlighted as well as their genomic potential. This review is a comprehensive study that compares the natural products recovered from the Red Sea in terms of ecological role and pharmacological activities.
海洋天然产物作为药物发现的新先导化合物的重要来源取得了巨大成功。红海在包括微生物和宏观生物在内的所有生命领域的生物尺度上都具有巨大的多样性。在这篇综述中，我们总结了来自红海微生物和宏观生物的生物活性次生代谢产物的多样性，并在适用的情况下讨论了它们的生物潜力。此外，还强调了红海生物的多样性及其基因组潜力。这是一项全面的研究，比较了从红海回收的天然产物在生态作用和药理活性方面的差异。
