Alderete J F
Department of Microbiology, University of Texas Health Science Center, San Antonio 78284-7758.
Genitourin Med. 1988 Apr;64(2):118-23. doi: 10.1136/sti.64.2.118.
Solco Trichovac is a vaccine of Lactobacillus acidophilus developed for treating trichomoniasis. The efficacy of the vaccine is reportedly due to cross reacting antibody being produced in people immunised with the lactobacillus bacteria. Several techniques, including enzyme linked immunosorbent, indirect immunofluorescence, immunoblot, and radioimmunoprecipitation assays were used to assess the extent of antigenic cross reactivity between Lactobacillus acidophilus and Trichomonas vaginalis. Data show a lack of antigenic relatedness between the Solco Trichovac lactobacilli and several strains of T vaginalis. Furthermore, antiserum to L acidophilus failed to inhibit trichomonad cytadherence or host cell killing, as is suggested by the producers of the Solco Trichovac vaccine.
索尔科滴虫疫苗(Solco Trichovac)是一种为治疗滴虫病而研发的嗜酸乳杆菌疫苗。据报道,该疫苗的有效性源于接种嗜酸乳杆菌的人产生了交叉反应抗体。采用了多种技术,包括酶联免疫吸附测定、间接免疫荧光、免疫印迹和放射免疫沉淀测定,以评估嗜酸乳杆菌与阴道毛滴虫之间抗原交叉反应的程度。数据显示,索尔科滴虫疫苗的嗜酸乳杆菌与几种阴道毛滴虫菌株之间缺乏抗原相关性。此外,正如索尔科滴虫疫苗生产商所指出的,针对嗜酸乳杆菌的抗血清未能抑制滴虫细胞黏附或宿主细胞杀伤。